Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 242-894-7 | CAS number: 19224-26-1
Endpoint summary
Administrative data
Description of key information
In a study performed to OECD guidelines and GLP (Huntingdon Life Sciences, 2014c; Klimisch score = 1), propylene glycol dibenzoate was determined to be readily biodegradable according to the "manometric respirometry test" (OECD 301F).
Annex IX of Regulation (EC) No 1907/2006, states that that long-term toxicity testing shall be proposed by the registrant if the results of the chemical safety assessment according to Annex I indicate the need to investigate further the effects of the substance and/or degradation products on terrestrial organisms.
There are no defined uses where direct exposure of this substance to the soil compartment is likely. Also, as this substance is readily biodegradable, it can be assumed that it will be biodegraded within the STP process and as a consequence indirect transfer to the soil compartment from sludge is not expected. Furthermore, the results from a read across earthworm study (Huntingdon Life Sciences, 1998e; Klimisch score = 1) have been used to assess the hazard to terrestrial organisms and further investigation of the effects of the substance and/or its breakdown products on additional terrestrial organisms is not justified and are waived.
Toxicity to soil macroorganisms except arthropods
There is no data available for propylene glycol dibenzoate (PGDB). Relevant information is available from a structural analogue Dipropylene glycol dibenzoate (DPGDB). The justification for read across is presented as an attachment included in Section 13 of the IUCLID dossier.
In an OECD Guideline 207 acute toxicity study in earthworms, conducted to determine the effects of DPGDB, no mortalities were observed and all worms were normal in appearance on days 7 and 14 of the test. Under the conditions of this study, the LC50 value of DPGDB to the earthworm was found to be in excess of 1000 ppm. The no observed effect level (NOEL) was considered to be 1000 ppm (Huntingdon Life Sciences, 1998e; Klimisch score = 1).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
