Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Boiling point

Currently viewing:

Administrative data

Endpoint:
boiling point
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Not guideline, GLP study but validated method with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004
Report date:
2004

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Dynamic heating mode at 3 ° C/min in sealed cells resistant stainless steel pressure under nitrogen and oxygen.
GLP compliance:
not specified
Type of method:
differential scanning calorimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
Heparin, sodium salt
Cas Number:
9041-08-1
IUPAC Name:
Heparin, sodium salt
Details on test material:
Batch n° ETA 1803

Results and discussion

Boiling point
Decomposition:
yes
Decomp. temp.:
190
Remarks on result:
other: Significant exotherm degradation with phenomenon end to 270 ° C (under nitrogen) and 280 °C (under oxygen)

Any other information on results incl. tables

Enthalpy under nitrogen: ∆H= -127 °C

Enthalpy under oxygen ∆H= -476 °C

Applicant's summary and conclusion

Conclusions:
The decomposition of the purified sodium heparinate started at 190°C.