Registration Dossier
Registration Dossier
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EC number: 261-853-4 | CAS number: 59673-82-4
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (48 and 96 h, Danio rerio) > 473 mg/L (measured concentration, corresponding to a nominal concentration of 500 mg/L);
Key value for chemical safety assessment
Additional information
In a 96 hour acute toxicity test with Danio rerio equivalent to OECD 203 and compliant to GLP (reliability category 2), toxicity of the submission substance to freshwater fish was tested. Due to the poor solubility of the test item in water a dispersion of the test substance was tested. In spite of the observed deposition of test item at the bottom of the test tank, the dispersion proved to be stable, as mean measured submission substance concentrations were 94.6% of nominal. A static test design was applied. Neither lethality nor abnormalities in behaviour or appearance were observed. However, at the limit concentration observation of symptoms was restricted due to turbidity of the test medium. The following effect values were determined:
Effect concentrations, nominal:
LC50 (24, 48, 72 and 96 hours) > 500 mg/L;
LC0 (24, 48, 72 and 96 hours) = 500 mg/L;
Effect concentrations, mean measured (94.6% of nominal concentration of 500 mg/L):
LC50 (24, 48, 72 and 96 hours) > 473 mg/L;
LC0 (24, 48, 72 and 96 hours) = 473 mg/L;
These data are corroborated by a database entry within ETOX-database (http://webetox.uba.de/webETOX/index.do) of the German federal enviornmental agency based on data of another, not publicly accessible database (GSBL-database, "gemeinsamer Stoffpool Bund-Länder). According to this entry, the LC50 of the submission substance in a toxicity test with Danio rerio was > 500 mg/L for 48 and 96 hours of incubation. According to the database entry the test was performed compliant to GLP. As no further data on purity of test material, experimental details or data source are available the quality / reliability of the data is not assignable (reliablity category 4).
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