Registration Dossier
Registration Dossier
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EC number: 404-986-7 | CAS number: 74227-35-3 BDS-HEXAFLUOROPHOSPHATE; BDS-HEXAFLUORPHOSPHAT; ESACURE 1004
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions.
Data source
Reference
- Reference Type:
- other: inquiry data
- Title:
- Unnamed
- Year:
- 2 014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V, B.6, maximization test
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- A mixture of: thiobis(4,1-phenylene)-S,S,S',S'-tetraphenyldisulfonium bishexafluorophosphate; diphenyl(4-phenylthiophenyl)sulfonium hexafluorophosphate
- EC Number:
- 404-986-7
- EC Name:
- A mixture of: thiobis(4,1-phenylene)-S,S,S',S'-tetraphenyldisulfonium bishexafluorophosphate; diphenyl(4-phenylthiophenyl)sulfonium hexafluorophosphate
- Cas Number:
- 74227-35-3
- IUPAC Name:
- (4-{[4-(diphenylsulfaniumyl)phenyl]sulfanyl}phenyl)diphenylsulfanium; diphenyl[4-(phenylsulfanyl)phenyl]sulfanium; tris(hexafluoro-λ⁵-phosphanuide)
Constituent 1
In vivo test system
Test animals
- Species:
- other: Pirbright White Guinea Pig(BOR:DHPW)
Study design: in vivo (non-LLNA)
Induction
- Concentration / amount:
- CONCENTRATION IN THE INDUCTION PERIOD: 50% epidermal
CONCENTRATION IN THE CHALLENGE PERIOD: 25% epidermal
Challenge
- Concentration / amount:
- CONCENTRATION IN THE INDUCTION PERIOD: 50% epidermal
CONCENTRATION IN THE CHALLENGE PERIOD: 25% epidermal
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Group:
- test chemical
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- other: Reading: 1st reading. Group: test group. No with. + reactions: 0.0. Total no. in groups: 20.0.
- Reading:
- 2nd reading
- Group:
- test chemical
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- other: Reading: 2nd reading. Group: test group. No with. + reactions: 0.0. Total no. in groups: 20.0.
- Reading:
- 1st reading
- Group:
- negative control
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- other: Reading: 1st reading. Group: negative control. No with. + reactions: 0.0. Total no. in groups: 20.0.
- Reading:
- 2nd reading
- Group:
- negative control
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Remarks on result:
- other: Reading: 2nd reading. Group: negative control. No with. + reactions: 0.0. Total no. in groups: 20.0.
Any other information on results incl. tables
NUMBER OF REACTING ANIMALS工N TEST AND CONTROL GROUP:
Treatment group:0/20 (24 and 48 hours)
Control group: 0/20 (24 and 48 hours)
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
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