Registration Dossier
Registration Dossier
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EC number: 210-856-9 | CAS number: 624-65-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP non-guideline, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 955
- Report date:
- 1955
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-chloropropyne
- EC Number:
- 210-856-9
- EC Name:
- 3-chloropropyne
- Cas Number:
- 624-65-7
- Molecular formula:
- C3H3Cl
- IUPAC Name:
- 3-chloroprop-1-yne
- Details on test material:
- - Name of test material (as cited in study report): Propargyl chloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 5% (low dose), 10% (mid- and high-doses) - Doses:
- 50, 100, 200, 400 mg/kg bw
- No. of animals per sex per dose:
- - 50 mg/kg bw: 5 females
- 100 mg/kg bw: 5 females
- 200 mg/kg bw: 4 males and 1 female
- 400 mg/kg bw: 4 males and 1 female - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 8 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 165 mg/kg bw
- Based on:
- test mat.
- Mortality:
- - 50 mg/kg bw: no mortality
- 100 mg/kg bw: 1 of the 5 female animals died
- 200 mg/kg bw: 3 of the 4 male animals and the female animal died
- 400 mg/kg bw: all animals died - Clinical signs:
- other: Clinical signs observed were cramps, heavy gait and nervousness
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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