Registration Dossier
Registration Dossier
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EC number: 216-074-4 | CAS number: 1490-04-6
Endpoint summary
Administrative data
Description of key information
Additional information
6.1.1 Short-term toxicity to fish
The test for d,l-menthol with fish (Danio rerio) a LC50 of 22.3 mg/L (geom. mean from nominal concentration) after 96 hours is obtained. The study was conducted according to Umweltbundesamt (UBA) -Verfahrensvorschlag: "Letale Wirkung beim Zebrabaerbling Brachydanio rerio, Mai 1984 (Bayer AG, 1990).
6.1.3 Short-term toxicity to aquatic invertebrates
Read across:
The acute toxicity of L-Menthol (CAS no. 2216-51-5) to invertebrates (Daphnia magna) was determined in a static immobilisation test according to EU Method C.2 (Acute Toxicity for Daphnia) which is similar to the OECD Guideline 202. After 48 hours of exposure an EC50 of 26.6 mg/L (measured) is obtained (Haarmann & Reimer, 2002).
6.1.5 Toxicity to aquatic algae and cyanobacteria
With a growth inhibition test according to EU Method C.3 (Algal Inhibition test) on alga (Desmodesmus subspicatus) a 72-hour EC50 of 16.01 mg/l and a 72 -hour NOEC of 2.31 mg/l was determined for DL-Menthol (1490 -04 -6). Effective concentrations are based on the arithmetic mean of measured concentrations (Haarmann&Reimer, 2000).
6.1.7 Toxicity to microorganisms
The toxicity of DL-Menthol (CAS no. 1490 -04 -6) to activated sludge was investigated according to ISO 8192 (Test for Inhibition of Oxygen Consumption by Activated Sludge). A EC50 of 306 mg/L after an exposure of 3 hours was observed (Bayer, 1989).
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