Registration Dossier
Registration Dossier
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EC number: 428-410-9 | CAS number: 67014-36-2
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
In contact with water the substance will hydrolyse slowly.
Key value for chemical safety assessment
Additional information
Hydrolysis of the test substance was studied in the dark at 50 ºC in sterile aqueous buffered solutions at pH 4 , pH 7 and pH 9 for 5 days. The experiment was conducted in accordance EU method C.7 and in compliance with the GLP standards. Samples were analysed at 0, 2.4 hours and 5 days by HPLC/UV. At test termination, the concentration of the test substance decreased from 100% at day 0, to 94% of the initial at pH 4, from 100 to 93% of the initial at pH 7, and from 100 to 95% of the initial at pH 9. No transformation of the test substance was observed.
At pH 4, pH 7 and pH 9, a decrease in concentration < 10% was observed after 5 days (half-life time at 25 °C > 1 year). Hence it was concluded that the test substance is hydrolytically stable at pH 4, pH 7 and pH 9, under the conditions of the test. (NOTOX B.V., 2000)
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