Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-351-8 | CAS number: 2422-91-5
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: Case report
- Adequacy of study:
- key study
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Concomitant alveolitis and asthma following exposure to triphenylmethane triisocyanate
- Author:
- J.B. Buick & G.R.G. Todd
- Year:
- 1 997
- Bibliographic source:
- Occup. Med. 47, 504-506
Materials and methods
- Type of sensitisation studied:
- respiratory
- Study type:
- case report
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
Test material
- Reference substance name:
- Methylidynetri-p-phenylene triisocyanate
- EC Number:
- 219-351-8
- EC Name:
- Methylidynetri-p-phenylene triisocyanate
- Cas Number:
- 2422-91-5
- Molecular formula:
- C22H13N3O3
- IUPAC Name:
- 1-[bis(4-isocyanatophenyl)methyl]-4-isocyanatobenzene
- Details on test material:
- - Name of test material (as cited in publication): "There was contact with various chemicals used in processing, one of which was later identified as triphenylmethane triisocyanate."
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not applicable
- Subjects:
- - Number of subjects exposed: one
- Sex: male
- Age: 36 - Clinical history:
- - History of allergy or casuistics for study subject or populations:
- Symptoms, onset and progress of the disease: 5-month history of increasing breathlessness, cough, 14 pounds weight loss and rigors.
- Exposure history: self-employed, working in a family-owned firm involved with rubber products
- Aggravating factors both in home and workplace: no data
- Family history: no data
- Medical history (for respiratory hypersensitivity): no childhood asthma or atopy
- Any other allergic or airway disorders:
- Smoking history: non-smoker - Route of administration:
- other: "...he had been using a cold cure adhesive to bond rubber to metal. He had spent 4 days applying the cold cure agent, by brush, to the inside of a large metal cylinder. No respiratory or skin protection was worn."
Results and discussion
- Results of examinations:
- RESULT OF CASE REPORT: "Pulmonary function tests demonstrated physiological abnormalities consistent with both asthma and alveolitis."
Applicant's summary and conclusion
- Executive summary:
A case report describes physiological abnormalities consistent with both asthma and alveolitis in a pulmonary function test of a male worker who had contact with various chemicals used in processing, one of which was later identified as triphenylmethane triisocyanate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
