Registration Dossier
Registration Dossier
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EC number: 219-764-3 | CAS number: 2526-62-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study did not comply with current guidelines for acute inhalation testing.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- To investigate the effects of inhaling a substantially saturated vapour of test substance.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-(trimethoxysilyl)propiononitrile
- EC Number:
- 219-764-3
- EC Name:
- 3-(trimethoxysilyl)propiononitrile
- Cas Number:
- 2526-62-7
- Molecular formula:
- C6H13NO3Si
- IUPAC Name:
- 3-(trimethoxysilyl)propanenitrile
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- ca. 6 h
- Concentrations:
- "Substantially saturated vapour"
- No. of animals per sex per dose:
- Five
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Remarks on result:
- other: Not determined as only two of 10 animals died at the single concentration tested.
Any other information on results incl. tables
Two male (no female) rats died following a single 6-hour inhalation exposure to substantially saturated vapour of Y-9445. Both had dark red lungs at necropsy. Signs of toxicity for males and females included hypoactivity, salivation, lacrimation, dermal irritation (erythema), coordination loss and prostration.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a non-guideline acute inhalation study, not conducted to GLP, the LC50 for 3-(trimethoxysilyl)propiononitrile was greater than the "substantially saturated vapour".
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