Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
247-714-0
CAS no.:
26447-40-5
Index number:
Molecular formula:
SMILES:
InChI:
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
2
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance causes serious eye irritation, is harmful if inhaled, is suspected of causing cancer, may cause damage to organs through prolonged or repeated exposure, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory irritation.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is fatal if inhaled and causes damage to organs.

Breakdown of all 1231 C&L notifications submitted to ECHA

Eye Irrit. 2 H319 Harmonised Classification
Skin Irrit. 2 H315 Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
Resp. Sens. 1 H334 Harmonised Classification
STOT RE 2 H373 Harmonised Classification
Carc. 2 H351 Harmonised Classification
STOT SE 3 H335 Harmonised Classification
Acute Tox. 4 H332 Harmonised Classification
Acute Tox. 2 H330
STOT SE 3 H370
Not Classified
Acute Tox. 4 H302
STOT SE 2 H335
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
Suspected to be Carcinogenic (Harmonised C&L).
  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (96.99% of CLP notifications).
  • Sr
Officially recognised in the EU as Respiratory sensitising ( Harmonised C&L).
  • Sr
There is broad agreement in that a majority of data submitters agree this substance is Respiratory sensitising (96.99% of CLP notifications).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 0 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):
Some uses of this substance are restricted under Annex XVII of REACH.

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance has not been registered under the REACH Regulation, therefore as yet ECHA has no usable data available about this substance from registered dossiers.

This substance is used at industrial sites.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following areas: scientific research and development.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure and closed batch processing in synthesis or formulation.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Arcerion GmbH, Gabrielenstr. 15 80636 Muenchen Germany

Substance names and other identifiers

4,4'-,2,4'-,2,2'-Diisocyanatodiphenylmethane
Other
4,4’ diphenylmethanediisocyanate, isomere, homologe and mixtures
Other
Benzene, 1,1'-methylenebis(isocyanato-
Other
Diphenylmethane diisocyanate
Other
Isocyanic acid, methylenediphenylene ester
Other
Methylenebis(phenyl isocyanate)
Other
Methylenediphenyl diisocyanate
EC Inventory, C&L Inventory, REACH pre-registration, Other, , , , , , ,
Methylenediphenyl diisocyanate (MDI)
Restriction list
polymethylenpolyfenylisokyanát
Other
Reaction mass of 4,4'-methylenediphenyl diisocyanate and 2,2'-methylenediphenyl diisocyanate and o-(p-isocyanatobenzyl)phenyl isocyanate
Other
2,2'-diizocianat de difenil-metan (ro)
C&L Inventory
diisocianato de metilendifenilo (es)
C&L Inventory
diisocianato de metilenodifenilo (pt)
C&L Inventory
diisocyanate de méthylènediphényle (fr)
C&L Inventory
diizocianat de metilen-difenil (mt)
C&L Inventory
diizocyjanian metylenodifenylu (pl)
C&L Inventory
methyleendifenyldiisocyanaat (nl)
C&L Inventory
methylendifenyl diisokyanát (cs)
C&L Inventory
methylendiphenyldiisocyanat (da)
C&L Inventory
metilendifenil diizocianat (hr)
C&L Inventory
metilendifenildiizocianatas (lt)
C&L Inventory
metilendifenilediisocianato (it)
C&L Inventory
metiléndifenil-diizocianát (hu)
C&L Inventory
Metilēndifenildiizocianāts (lv)
C&L Inventory
metyleenidifenyylidi-isosyanaatti (fi)
C&L Inventory
metylendifenyldiisocyanat (no)
C&L Inventory
metyléndi(fenylizokyanát) (sk)
C&L Inventory
metüleendifenüüldiisotsüanaat (et)
C&L Inventory
διισοκυανικό μεθυλενοδιφαινύλιο (el)
C&L Inventory
метилендифенил диизоцианат (bg)
C&L Inventory
Benzene, 1,1'-methylenebis[isocyanato-
Other
1,1'- Methylenebis [isocyanatobenzene]
C&L Inventory
1,1'-methylenebis(2-isocyanatobenzene)
C&L Inventory
1,1'-methylenebis(4-isocyanatobenzene)
C&L Inventory
1,1'-Methylenebis(isocyanatobenzene)
C&L Inventory
1-isocyanato-4-[(4-isocyanatophenyl)methyl]
C&L Inventory
1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene
C&L Inventory, Registration dossier, Other
4,4'-Methylendiphenyldiisocyanat
C&L Inventory
4,4'-METHYLENEBIS(PHENYL ISOCYANATE)
C&L Inventory
Diphenylmethane diisocyanate (mdi)
C&L Inventory
DIPHENYLMETHANE-DI-ISOCYANATE
C&L Inventory
Diphenylmethane-diisocyanate
C&L Inventory
formaldehyde;isocyanatobenzene
Other
METHYLENE DIPHENYLISOCYANATE
C&L Inventory
Methylenediphenyl diisocyanate)
C&L Inventory
MDI
Restriction list
Methylenediphenyl diisocyanate, mixed isomers
REACH pre-registration
101840-81-7
CAS number
Other
103106-61-2
CAS number
Other
103812-90-4
CAS number
Other
107231-85-6
CAS number
Other
108021-94-9
CAS number
Other
111310-30-6
CAS number
Other
116439-26-0
CAS number
Other
120528-46-3
CAS number
Other
120797-37-7
CAS number
Other
12125-47-2
CAS number
Other
1228530-76-4
CAS number
Other
1262791-71-8
CAS number
Other
129406-02-6
CAS number
Other
1306717-73-6
CAS number
Other
133686-81-4
CAS number
Other
1342796-19-3
CAS number
Other
1352205-75-4
CAS number
Other
1360626-75-0
CAS number
Other
137397-93-4
CAS number
Other
138069-64-4
CAS number
Other
141255-78-9
CAS number
Other
1422250-40-5
CAS number
Other
143476-94-2
CAS number
Other
147445-25-8
CAS number
Other
153190-02-4
CAS number
Other
154102-11-1
CAS number
Other
154609-09-3
CAS number
Other
154766-26-4
CAS number
Other
1551129-98-6
CAS number
Other
156580-59-5
CAS number
Other
160477-36-1
CAS number
Other
162355-20-6
CAS number
Other
162628-81-1
CAS number
Other
172826-96-9
CAS number
Other
178464-28-3
CAS number
Other
183563-24-8
CAS number
Other
184539-09-1
CAS number
Other
1916516-88-5
CAS number
Other
203743-04-8
CAS number
Other
203944-48-3
CAS number
Other
208196-65-0
CAS number
Other
209252-36-8
CAS number
Other
211991-83-2
CAS number
Other
212569-27-2
CAS number
Other
219753-20-5
CAS number
Other
247940-58-5
CAS number
Other
26447-40-5
CAS number
EC Inventory, C&L Inventory, Restriction list, Registration dossier, REACH pre-registration, Other, , , , , , ,
283603-33-8
CAS number
Other
28515-38-0
CAS number
Other
300852-58-8
CAS number
Other
315680-13-8
CAS number
Other
327155-87-3
CAS number
Other
37291-69-3
CAS number
Other
37370-30-2
CAS number
Other
379692-85-0
CAS number
Other
39278-75-6
CAS number
Other
478809-08-4
CAS number
Other
484655-09-6
CAS number
Other
50814-42-1
CAS number
Other
51059-16-6
CAS number
Other
51810-20-9
CAS number
Other
54018-19-8
CAS number
Other
56273-49-5
CAS number
Other
59392-73-3
CAS number
Other
612824-05-2
CAS number
Other
615-005-00-9
Index number
C&L Inventory
61642-52-2
CAS number
Other
65916-89-4
CAS number
Other
66174-31-0
CAS number
Other
667447-28-1
CAS number
Other
69345-95-5
CAS number
Other
71061-20-6
CAS number
Other
74315-87-0
CAS number
Other
75026-14-1
CAS number
Other
76600-86-7
CAS number
Other
81031-80-3
CAS number
Other
81406-01-1
CAS number
Other
83271-42-5
CAS number
Other
83271-43-6
CAS number
Other
83512-90-7
CAS number
Other
85497-20-7
CAS number
Other
86473-20-3
CAS number
Other
87139-88-6
CAS number
Other
87347-64-6
CAS number
Other
875453-93-3
CAS number
Other
88385-52-8
CAS number
Other
88651-68-7
CAS number
Other
9016-87-9
CAS number
Other
912469-29-5
CAS number
Other
913174-25-1
CAS number
Other
94469-81-5
CAS number
Other
96595-70-9
CAS number
Other
97397-19-8
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Data not provided by the registrant

Melting/freezing point

Data not provided by the registrant

Boiling point

Data not provided by the registrant

Density

Data not provided by the registrant

Vapour pressure

Data not provided by the registrant

Partition coefficient

Data not provided by the registrant

Water solubility

Data not provided by the registrant

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Data not provided by the registrant

Flash point

Data not provided by the registrant

Auto flammability

Data not provided by the registrant

Flammability

Data not provided by the registrant

Explosiveness

Data not provided by the registrant

Oxidising

Data not provided by the registrant

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Data not provided by the registrant

Viscosity

Data not provided by the registrant

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Data not provided by the registrant

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Data not provided by the registrant

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Data not provided by the registrant

Bioaccumulation: aquatic / sediment

Data not provided by the registrant

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Data not provided by the registrant

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

Data not provided by the registrant

Short–term toxicity to fish

Data not provided by the registrant

Long–term toxicity to fish

Data not provided by the registrant

Short–term toxicity to aquatic invertebrates

Data not provided by the registrant

Long–term toxicity to aquatic invertebrates

Data not provided by the registrant

Toxicity to aquatic algae and cyanobacteria

Data not provided by the registrant

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Data not provided by the registrant

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Data not provided by the registrant

Toxicity to terrestrial arthropods

Data not provided by the registrant

Toxicity to terrestrial plants

Data not provided by the registrant

Toxicity to soil microorganisms

Data not provided by the registrant

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

Data not provided by the registrant

Toxicokinetics, metabolism, and distribution

Data not provided by the registrant

Acute toxicity

Data not provided by the registrant

Irritation / corrosion

Data not provided by the registrant

Sensitisation

Data not provided by the registrant

Repeated dose toxicity

Data not provided by the registrant

Genetic toxicity

Data not provided by the registrant

Carcinogenicity

Data not provided by the registrant

Toxicity to reproduction

Data not provided by the registrant

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant