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EC number: 436-010-0 | CAS number: 422278-61-3 PRIMID V40-32
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From June 13th to June 19th, 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 0.23
- Temp.:
- 21 °C
- pH:
- ca. 7
- Conclusions:
- Partition coefficient of the substance was determined to be:
Log Pow = 0.23
using the flask shaking method. - Executive summary:
The determination of the partition coefficient (logPow) of the substance was performed using the flask shaking method as described in OECD guideline No. 107. During the study, three tests were carried out, each in duplicate, with volume ratios of both solvents of 1:1, 2:1 and 1:2. After equilibration, the concentration of the test item was determined in every phase by HPLC. The log Pow was calculated for each of the six vessels and was found to be in the range of 0.22 to 0.23.
In order to check the analytical work, the mass balance for each vessel was calculated, too, and the recovery of the test item was found to be in the range 98 -101%.
Reference
Description of key information
In a study according to OECD TG 107 (shake flask method), Log Pow was determined to be 0.23 at 21 °C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.23
- at the temperature of:
- 21 °C
Additional information
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