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EC number: 453-490-7 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 August 2003 to 30 October 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- Organization for Economic Co-operation and Development (OECD), OECD guidelines for testing of chemicals no.107: "Partiton coeffcient (n-octanor/water): Shake Flask Method", Adopted July 27,1995,
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- European Economic Community (EEC), EEC directive 92/69 EEC, Part A, Methods for the determination of physico-chemical properties, A.8: "Partition coeffcient", EEC Publication no. L383, December 1992.
- Deviations:
- not specified
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- No further details specified in the study report.
- Analytical method:
- not specified
- Key result
- Type:
- log Pow
- Partition coefficient:
- >= 8
- Temp.:
- 20.3 °C
- Remarks on result:
- other: pH not specified
- Key result
- Type:
- Pow
- Partition coefficient:
- 1 100 000
- Temp.:
- 20.3 °C
- Remarks on result:
- other: pH not specfieid
- Details on results:
- 1 ml n-octanol was added to 1031.6 mg of the test substance in a reaction tube. The solution was clear and no undissolved test substance was observed. After 6 days of stirring all test substance was still dissolved. Based on this, it was concluded that the n-octanol solubility of Hatcol 5150 is ≥ 1.0e+3 g/l at 20.0 ± 0.5 °C.
- Conclusions:
- The partition coefficient (n-octanol/water), Pow, calculated as a quotient of the n-octanol solubility and the water solubility of Hatcol 5150, is ≥ 1.1E+8 (log Pow ≥8 .0) at 20.3 ± 0.8 °C.
- Executive summary:
The determination of the partition coefficient (n-octanol/water) of Hatcol 5150 was based on the following guidelines:
Organization for Economic Co-operation and Development (OECD), OECD guidelines for testing of chemicals no.107: "Partiton coeffcient (n-octanollwater): Shake Flask Method", Adopted July 27, 1995.
EEC directive 92/69 EEC, Part A, Methods for the determination of physico-chemical properties, A.8: "Partition coefficient", EEC Publication no. L383. December 1992.
The Estimation method was performed for the determination of the partition coefficient (n-octanol/water), Pow of Hatcol 5150.
Estimation method
The n-octanol solubility of Hatcol 5150 was determined to be ≥ 1.0x103 g/l at 20.0 ± 0.5 °C
The water solubility of Hatcol 5150 at 20.4 ± 0.7 °C is < 9x10-8 g/l (see NOTOX project 388024).
The pH was measured to be 7.8 -7.9.
The partition coefficient (n-octanol/water), Pow, calculated as a quotient of the n-octanol solubility and the water solubility of Hatcol 5150, is ≥ 1.1x108 (log Pow ≥8 .0) at 20.3 ± 0.8 °C.
Reference
Description of key information
The partition coefficient (n-octanol/water), Pow, calculated as a quotient of the n-octanol solubility and the water solubility of Hatcol 5150, is ≥ 1.1x108(log Pow ≥8 .0) at 20.3 ± 0.8 °C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 8
- at the temperature of:
- 20 °C
Additional information
The Estimation method was performed for the determination of the partition coefficient (n-octanol/water), Pow of Hatcol 5150.
Estimation method
The n-octanol solubility of Hatcol 5150 was determined to be ≥ 1.0x103 g/l at 20.0 ± 0.5 °C
The water solubility of Hatcol 5150 at 20.4 ± 0.7 °C is < 9x10-8 g/l.
The pH was measured to be 7.8 -7.9.
The partition coefficient (n-octanol/water), Pow, calculated as a quotient of the n-octanol solubility and the water solubility of Hatcol 5150, is ≥ 1.1x108 (log Pow ≥8 .0) at 20.3 ± 0.8 °C.
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