Registration Dossier
Registration Dossier
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EC number: 609-206-0 | CAS number: 361366-16-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to OECD/EU guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- ethyl 1-[2-(2,4-dichlorophenyl)acetoxy]cyclohexanecarboxylate
- Cas Number:
- 361366-16-7
- Molecular formula:
- C17H20Cl2O4
- IUPAC Name:
- ethyl 1-[2-(2,4-dichlorophenyl)acetoxy]cyclohexanecarboxylate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Cremophor EL 2 % (v/v)
- Doses:
- 2000 mg(kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Clinical Signs
At doses of 2000 mg/kg no clinical signs were detected.
Body Weights
There were no lexicological effects on body weights or on body weight development in males and females.
Gross Pathology Findings
No gross pathologic changes were observed in animals sacrificed at the end of the study period. One male died on day 10 of the study. At the necropsy performed general autolysis was found.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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