Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 400-100-8 | CAS number: 84057-97-6 BLEU N-RM 2114; BLEU NYLOSAN N-BLN; BLUE N-RM 2114; NYLOSAN BLAU N-BLN; NYLOSAN BLEU N-BLN; NYLOSAN BLUE N-BLN
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Only data summary seen from SNIF docs
Data source
Reference
- Reference Type:
- other: ECHA
- Title:
- Unnamed
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- Sodium 1-amino-4-[2-methyl-5-(4-methylphenylsulfonylamino)phenylamino]anthraquinone-2-sulfonate
- EC Number:
- 400-100-8
- EC Name:
- Sodium 1-amino-4-[2-methyl-5-(4-methylphenylsulfonylamino)phenylamino]anthraquinone-2-sulfonate
- Cas Number:
- 84057-97-6
- Molecular formula:
- C28H22N3NaO7S2
- IUPAC Name:
- sodium 1-amino-4-[2-methyl-5-(4-methylphenylsulfonylamino)phenylamino]anthraquinone-2-sulfonate
- Details on test material:
- Not defined in record seen - SNIF
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- male/female
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- water
- Concentration / amount:
- 5% for injections
25% for topical challenges with material soaked onto paper
Challengeopen allclose all
- Route:
- epicutaneous, semiocclusive
- Vehicle:
- water
- Concentration / amount:
- 5% for injections
25% for topical challenges with material soaked onto paper
- No. of animals per dose:
- 10 male and 10 female
5 male and 5 female used as control
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other:
- Group:
- test chemical
- Dose level:
- 25% challenge
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- No adverse effects reported
- Remarks on result:
- other: Reading: other:. Group: test group. Dose level: 25% challenge. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: No adverse effects reported.
Any other information on results incl. tables
Very little detail provided in the NONS summary
Applicant's summary and conclusion
- Conclusions:
- Data obtained through ECHA Inquiry under the 12 year rule.
- Executive summary:
other: not classified
Data obtained through ECHA Inquiry under the 12 year rule.
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