Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-146-4 | CAS number: 765-43-5
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-01-12 - 1998-03-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: according to OECD301C (MITI I), GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Version / remarks:
- Japan’s 1973 Law Concerning the Evaluation of Chemical Substances and Regulation of their Manufacture, etc.
- Deviations:
- not applicable
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Cyclopropyl methyl ketone
- EC Number:
- 212-146-4
- EC Name:
- Cyclopropyl methyl ketone
- Cas Number:
- 765-43-5
- Molecular formula:
- C5H8O
- IUPAC Name:
- 1-cyclopropylethan-1-one
- Details on test material:
- - Physical state: liquid
- Analytical purity: 99.9%
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge : Stanadard activated sludge purchased from Chemicals Evaluation and Research Institute, Japan
- Storage conditions: 25 +- 2C pH7 +- 1
- Concentration of sludge: 30 mg/L
- Water filtered: no - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 100 mg/L
Parameter followed for biodegradation estimationopen allclose all
- Parameter followed for biodegradation estimation:
- O2 consumption
- Parameter followed for biodegradation estimation:
- DOC removal
- Parameter followed for biodegradation estimation:
- test mat. analysis
- Details on study design:
- TEST CONDITIONS
- Composition of medium: phosphate buffer, MgSO4, CaCl2, FeCl3
- Solubilising agent (type and concentration if used): not used
- Test temperature: 25 +- 1 C
- pH: 7.2
- pH adjusted: yes/no
- Aeration of dilution water: no
- Suspended solids concentration: 100 mg/L
- Inocolum concentration: 30 mg/L
TEST SYSTEM
- Culturing apparatus: Coulometer OM-2001 (Okura )
- Number of culture flasks/concentration: 3
- Method used to create aerobic conditions: 3
- Method used to create anaerobic conditions: 0
- Measuring equipment: Coulometer OM-2001 (Okura )
SAMPLING
- Sampling frequency: after 28 day exposure
- Sampling method: direct sampling
CONTROL AND BLANK SYSTEM
- Inoculum blank: 1
- Abiotic sterile control: 0
- Toxicity control: 0
- Water blank: 1
Reference substance
- Reference substance:
- aniline
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- 43
- Sampling time:
- 28 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 57
- Sampling time:
- 28 d
- Parameter:
- % degradation (test mat. analysis)
- Value:
- >= 99
- Sampling time:
- 28 d
BOD5 / COD results
- Results with reference substance:
- Aniline's BOD(%) after 7 days was 49% and passed the criteria ( 7days >40%)
Applicant's summary and conclusion
- Executive summary:
% degradation from BOD was 38, 45, and 45 % (ave. 43 %), % degratation from test material analysis was >=99 %, and % degration from DOC residue was 58, 56, and 56 % (ave. 57 %). Another peak except the test substance was detected in GC chromatogram and the peak was determined to be Cyclopropanol by 1H-NMR, GC/MS analysis. Therefore 1-Cyclopropylethanone is deemed to be not readily biodegradable and to remain as Cycropropanol.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
