Registration Dossier
Registration Dossier
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EC number: 245-178-2 | CAS number: 22722-98-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- up-and-down procedure
Test material
- Reference substance name:
- Sodium dihydridobis(2-methoxyethanolato)aluminate(1-)
- EC Number:
- 245-178-2
- EC Name:
- Sodium dihydridobis(2-methoxyethanolato)aluminate(1-)
- Cas Number:
- 22722-98-1
- Molecular formula:
- C6H16AlO4.Na
- IUPAC Name:
- sodium dihydridobis(2-methoxyethanolato)aluminate(1-)
- Details on test material:
- 70% hydride solution in Toluene carrier (as supplied)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Range from 55mg/kg bw to 2,000 mg.kg bw
- No. of animals per sex per dose:
- 9 Females total (Up&Down Procedure)
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 639.2 mg/kg bw
- Based on:
- dissolved
- 95% CL:
- > 0 - 20
- Mortality:
- 4 high dose animals
- Clinical signs:
- Hunched posture, piloerection, hypoactivity, reduced fecal volume in animals dosed >= 550 mg/kg bw
- Body weight:
- All but one animals gained body weight during teh 14-day observation period.
- Gross pathology:
- Discolouration of Lungs and intestines at highest dose only (2000mg/kg bw)
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- It is difficult to seperate the effects due to presence of 30% toluene carrier (required for stability).
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