Registration Dossier
Registration Dossier
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EC number: 257-036-7 | CAS number: 51181-50-1
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The lowest available NOEC -based on read across - was considered key for deriving this endpoint. The NOEC from the 21 d study with EDTA-Na2H2, 25 mg/L, corresponds to 26.3 mg/L HEDTAFeNa.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 26.3 mg/L
Additional information
Two reliable long term studies are available which can be used for assessments.
The long-term toxicity of EDTA-Na2H2 on Daphnia magna was measured in an reproduction test according to GLP criteria [BASF AG, 1998]. After 21 days of exposure a NOEC of 25 mg/L was observed (equivalent to 26.3 mg/L HEDTA-FeNa).
Another study with DTPA acid as well as Fe complexed DTPA confirmed low toxicity of the Fe complex substance, a NOEC was established at 67 mg/L DTPAFeNa2, which would correspond to 48.3 mg/L HEDTA-FeNa.
For justification for read-across see IUCLID 5, Chapter 13, however the lowest of the two NOECs is the proposed key information.
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