Registration Dossier
Registration Dossier
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EC number: 415-430-8 | CAS number: 86403-32-9 CYASORB UV-3853 LIGHT STABILIZER; DASTIB 845; SANDUVOR 845
Endpoint summary
Administrative data
Description of key information
The substance does not display acute toxicity, as seen by the high values for the LD50/LC50 for oral, dermal or inhalation routes of administration in rat and rabbit model systems.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 15 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 5 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
The acute oral LD50 is greater than 15,000 mg/kg bw, the acute dermal LD50 is greater than 5,000 mg/kg, and the acute inhalation LC50 is greater than 5 mg/m³. The substance does not display acute toxicity, as seen by these high values for the LD50 for oral or dermal routes of administration in rat and rabbit model systems. For inhaltion route of administration the highest achievable exposure concentration of 5 mg/m³ did not show any deaths or clinical signs compared to control group. In addition, the inhalation route is not appropriate, as the substance is a waxy solid and does not form particles which are inhalable.
Justification for classification or non-classification
None of the values for LD50/LC50 for oral, dermal or inhalation administration meets the criteria for classification for acute toxicity, according to Regulation (EC) No. 1272/2008.
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