Registration Dossier
Registration Dossier
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EC number: 483-350-0 | CAS number: -
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 May - 20 Jun 2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- 1992
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 2019
- Deviations:
- yes
- Remarks:
- Fish were slightly bigger than the recommended 1-2 cm (mean 3.29 cm) and only 4 concentrations were tested instead of 5.
- GLP compliance:
- yes (incl. QA statement)
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Test material form:
- liquid
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 255 mg/L CaCO3
- Nominal and measured concentrations:
- - Nominal concentrations: 0.625, 1.25, 2.5, 5 mg/L
- Measured concentrations (new at 0h): 0.601, 1.225, 2.518, 4.924 mg/L
- Measured concentrations (new at 78h): 0.512, 1.110, 2.262, - mg/L
- Measured concentrations (old at 24 h): 0.229, 0.256, 1.210, 2.08 mg/L
- Measured concentrations (old at 96 h): 0.342, 0.596, 1.291, - mg/L
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.86 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.71 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% confidence limits: 1.37 - 2.14 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 0.67 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The effect value for the short-term toxicity to fish is LC50 (96 h) = 1.71 mg/L (geom. mean) and LC0 (96h) = 0.67 mg/L (geom. meanl).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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