4-chloro-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine

Explosiveness

Administrative data

Endpoint:

explosive properties of explosives

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2021-06-17 to 2021-06-25

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2021

Report date:

2021

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.14 (Explosive properties)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

4-chloro-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine

Cas Number:

2270944-70-0

Molecular formula:

C15H16ClN5O4

IUPAC Name:

4-chloro-N-[2-methoxy-4-(morpholin-4-yl)-5-nitrophenyl]pyrimidin-2-amine

Test material form:

solid: particulate/powder

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Batch (Lot) Number: I20CD1048
- Purity/Composition: 100%
- Purity test date : 2020-05-11
- Expiry date: 2022-03-22 (retest date)
- Physical Description: Light yellow to dark orange solid

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
- Stability and homogeneity of the test material in the vehicle/solvent under test conditions and during storage: not indicated
- Stability in the medium, i.e. sensitivity of the test material to hydrolysis and/or photolysis: not indicated
- Solubility and stability of the test material in the solvent/vehicle and the exposure medium: not indicated
- Reactivity of the test material with the incubation material used (e.g. plastic ware): not indicated

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
No treatment

Results and discussion

Small-scale preliminary tests

Small-scale preliminary tests 1

Key result

Parameter:

sensitiveness to impact: impact energy (J)

Remarks on result:

not sensitive to impact using an impact energy of 40 J

Remarks:

The test item of JNJ-73848242-AAA (T003901) was observed to exhibit no reaction at 40 J.

Small-scale preliminary tests 2

Key result

Parameter:

sensitiveness to friction: friction load (N)

Remarks on result:

not sensitive to friction using a friction load of 360 N

Remarks:

The test item of JNJ-73848242-AAA (T003901) was observed to exhibit no reaction at 360 N.

Small-scale preliminary tests 3

Key result

Parameter:

thermal sensitivity - Koenen test: diameter of the orifice plate

Remarks on result:

thermal sensitive if heated under defined confinement

Remarks:

The test item did not exhibit an explosion during any of the tests.

Any other information on results incl. tables

1. BAM FALLHAMMER: Test Procedure

The test item was placed in the impact device and the 10 kg weight dropped from a height of 40 cm which is equivalent to 40 J. If an "explosion" was observed, the impact energy was reduced to 7.5 J and further tests conducted.

Table 8:1: Test Results

Mass (kg)	Height (m)	Energy (J)	Test number and result* (X / ✓)	Comments
10	0.4	40	1 2 3 4 5 6 X X X X X X	No reaction

* ‘✓’ denotes an explosion (includes crackling, sparking, inflammation).
‘X’ denotes no reaction or decomposition (change in colour).

2. BAM FRICTION: Test procedure

Table 9:1: Test Results

Mass (kg)	Load (N)	Test number and result* (X / ✓)	Comments
10	360	1 2 3 4 5 6 X X X X X X	No reaction

* ‘✓’ denotes an explosion (includes crackling, sparking, inflammation).
‘X’ denotes no reaction or decomposition (change in colour).

3. KOENEN TUBE: Test procedure

Table 10:1 : Full test results

Mass of test item (g)	Orifice Diameter (mm)	Time for First Ignition (s)	Explosion (X / ✓)*
16.3	6	14	X
16.3	6	15	X
16.3	6	15	X
16.3	2	10	X
16.3	2	11	X
16.3	2	11	X

* ‘✓’ denotes 3 or more fragments.
‘X’ denotes fewer than 3 fragments.

 

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

BAM FALLHAMMER Test: The test item of JNJ-73848242-AAA (T003901) was observed to exhibit no reaction at 40 J. The test result is therefore considered Negative (-) (according to the EC
Classification, Packaging & Labelling of Dangerous Substances in the European Union
Part 2, Testing Methods, Jan 97).

BAM FRICTION Test: The test item of JNJ-73848242-AAA (T003901) was observed to exhibit no reaction at 360 N. The test result is therefore considered Negative (-) (according to the EC
Classification, Packaging & Labelling of Dangerous Substances in the European Union
Part 2, Testing Methods, Jan 97).

KOENEN TUBE Test: The test item did not exhibit an explosion during any of the tests. The test result is therefore considered Negative (-) (according to the EC Classification, Packaging &
Labelling of Dangerous Substances in the European Union Part 2, Testing Methods, Jan 97).