Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Flammability
Administrative data
- Endpoint:
- self-heating substances / mixtures
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 Jan 2021 to 17 Mar 2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)
- Deviations:
- no
Test material
- Reference substance name:
- N-[4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl]-6-methoxy-4-(morpholin-4-yl)benzene-1,3-diamine
- Cas Number:
- 1903009-56-2
- Molecular formula:
- C27H32N8O2
- IUPAC Name:
- N-[4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]pyrimidin-2-yl]-6-methoxy-4-(morpholin-4-yl)benzene-1,3-diamine
- Test material form:
- solid: particulate/powder
1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Batch (Lot) Number: I20ID2980
- Purity/Composition: 95.0%
- Purity/Composition correction factor: 1.0
- Purity test date : 2020-10-26
- Expiry date: 17 September 2022 (retest date)
- Physical Description: Beige powder
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
Results and discussion
Self-heating substances / mixtures
- Key result
- Test procedure:
- 100 mm sample cube at 140°C
- Result:
- negative outcome (no effect observed)
Any other information on results incl. tables
A negative result was obtained. No spontaneous ignition occurred and no exothermic effect of the test item was observed. It demonstrated that the test item is “not a self-heating substance”. According to the UN guideline, no further testing is required.
After the experiment, the test item had turned into a light brown residue. It indicated that the test item had been decomposed and/or reacted during the experiment.
Applicant's summary and conclusion
- Conclusions:
- Self-heating of JNJ-73848281-AAA (T003904) was determined in accordance with UN Test N.4 “Test Method for Self-heating Substances”.
From the negative result obtained at 140°C using a 10 cm sample cube, it was concluded that JNJ-73848281-AAA (T003904) is not a self-heating substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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