Registration Dossier
Registration Dossier
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EC number: 840-148-0 | CAS number: 308831-94-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- (Q)SAR prediction.
Data source
Reference
- Reference Type:
- other: (Q)SAR prediction
- Title:
- Unnamed
- Year:
- 2 022
- Report date:
- 2022
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on (Q)SARs R.6., May/July 2008
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethyl 2-[[(2,6-difluorophenyl)methyl](ethoxycarbonyl)amino]-4-methyl-5-(4-nitrophenyl)-3-thiophenecarboxylate
- EC Number:
- 840-148-0
- Cas Number:
- 308831-94-9
- Molecular formula:
- C24H22F2N2O6S
- IUPAC Name:
- Ethyl 2-[[(2,6-difluorophenyl)methyl](ethoxycarbonyl)amino]-4-methyl-5-(4-nitrophenyl)-3-thiophenecarboxylate
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: gavage
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 040 mg/kg bw
- Remarks on result:
- other: (Q)SAR prediction
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- According to (Q)SAR model, using (Q)SAR Toolbox 4.5, the predicted LD50 value of Ethyl 2-[[(2,6-difluorophenyl)methyl](ethoxycarbonyl)amino]-4-methyl-5-(4-nitrophenyl)-3-thiophenecarboxylateis 1040 mg/kg.
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