Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE EPI-SUITE EPA (USA) v 4.11
2. MODEL (incl. version number) BIOWIN v4.10
3. SMILES C1CCN(C(=O)C1)c2ccc(cc2)N3CCC=C(C3(=O))N4CCOCC4
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL The QMRF is available in "Attached justification".
5. APPLICABILITY DOMAIN The QPRF is available in “Attached justification”.
6. ADEQUACY OF THE RESULT The QPRF is available in “Attached justification”. - Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Howard, P.H., Boethling, R.S., Stiteler, W.M., Meylan, W.M., Hueber, A.E., Beauman, J.A., Larosche, M.E. 1992. Predictive model for aerobic biodegradability developed from a file of evaluated biodegradation data. Environ. Toxicol. Chem. 11:593-603.
- GLP compliance:
- no
- Specific details on test material used for the study:
- SMILES: C1CCN(C(=O)C1)c2ccc(cc2)N3CCC=C(C3(=O))N4CCOCC4
- Key result
- Parameter:
- probability of ready biodegradability (QSAR/QSPR)
- Remarks on result:
- not readily biodegradable based on QSAR/QSPR prediction
- Validity criteria fulfilled:
- not applicable
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The test item is predicted to be not readily biodegradable (EPISUITE, BIOWIN v4.10).
- Executive summary:
According to EPISUITE model BIOWIN v4.10, the substance is predicted to be not readily biodegradable.
Reference
Description of key information
Key Study. Data from EPI-Suite, EPA (USA) / BIOWIN v4.10 calculation method. The test substance was predicted to be not ready biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
