Registration Dossier
Registration Dossier
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EC number: 206-496-7 | CAS number: 350-03-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Oral Toxicity Determination of Methyl Pyridyl Ketone in the Rat
- Author:
- A.C.Costelloa, R.C. Myersb, C.E. Manderfielda, T.G. Osimitza
- Year:
- 1 990
- Bibliographic source:
- Thompson, W.R., 1947, Bact. Rev. 11 :115-145
Weil, C., 1983, Drug and Chemical Toxicology, 6(6), 595-603
Materials and methods
- Principles of method if other than guideline:
- Method not published.
- GLP compliance:
- not specified
- Test type:
- other: not specified
Test material
- Reference substance name:
- Methyl 3-pyridyl ketone
- EC Number:
- 206-496-7
- EC Name:
- Methyl 3-pyridyl ketone
- Cas Number:
- 350-03-8
- Molecular formula:
- C7H7NO
- IUPAC Name:
- 1-(pyridin-3-yl)ethan-1-one
1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- three dosage levels ranging from 0.0312 mI/kg to 0.0625 ml/kg
- No. of animals per sex per dose:
- 5/sex/group
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 0.046 mL/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.052 mL/kg bw
Any other information on results incl. tables
Clinical signs included sluggishness, an unsteady gait, gasping, pale
extremities, prostration, convulsions, emaciation, a red crust on the perinasal
and periocluar fur, and blood in the urine.
Necropsy of rats that died revealed red and/or mottled lungs, red or brown
stomachs, discolored intestines (yellow to red) and dark red livers. Survivors
had no remarkable lesions.
Applicant's summary and conclusion
- Conclusions:
- Males LD50 = 0.052 mI/kg (95% CL = 0.045 - 0.061 ml/kg)
Females LD50 = 0.046 ml/kg (95% CL = 0.028 - 0.073 ml/kg)
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