Registration Dossier
Registration Dossier
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EC number: 425-180-1 | CAS number: 66170-10-3
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.13, B.14; OECD 471, 472
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- -
- EC Number:
- 425-180-1
- EC Name:
- -
- Cas Number:
- 66170-10-3
- Molecular formula:
- C6H6Na3O9P
- IUPAC Name:
- trisodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-5-oxo-4-(phosphonatooxy)-2,5-dihydrofuran-3-olate
- Test material form:
- solid: particulate/powder
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: sat TA 98, 100, 1535, 1537; esc WP2 uvrA bacteria
- Metabolic activation system:
- Aroclor-induced rat liver S9 mix
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 24 ... 6000 µg/plate
Concentration range in the main test (without metabolic activation): 24 ... 6000 µg/plate - Vehicle / solvent:
- Solvent: water
- Details on test system and experimental conditions:
- Concentration of the test substance resulting in precipitation: 0 µg/plate
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- >= 3000 µg/plate
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- >= 3000 µg/plate
- Additional information on results:
- Observations:
Only in single strains a slight reduction of the numbert of revertants in dependance from the test strain and the test conditions were observed. - Remarks on result:
- other: main test Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
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