Registration Dossier
Registration Dossier
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EC number: 946-850-4 | CAS number: -
Endpoint summary
Administrative data
Description of key information
No in vitro skin sensitisation tests were performed with the test item because the available in vitro test methods are not applicable for the substance. The test item is not soluble in any solvents listed for the LuSens or h-CLAT test. The DPRA test was not conducted because it is not a stand-alone test. Therefore, two in silico tools (OECD QSAR Toolbox, Toxtree) were used to identify alerts for skin sensitisation potential for the three constituents of the test item.
No skin sensitisation reactivity domain alerts were identified by Toxtree and no protein binding alerts were identified by QSAR Toolbox for none of the three constituents. Therefore, it can be concluded that there is no indication for a skin sensitizing potential of the test item.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- other: in silico tool
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Principles of method if other than guideline:
- Profilers:
General Mechanistic
Protein binding potency GSH
Protein binding by OECD
Protein binding by OASIS
Protein binding potency Cys (DPRA 13%)
Protein binding potency Lys (DPRA 13%)
Endpoint Specific
Protein binding alerts for skin sensitization according to GHS
Protein Binding Potency h-CLAT
Protein binding alerts for Chromosomal aberration by OASIS
Protein binding alerts for skin sensitization by OASIS - Type of study:
- other: in silico tool
- Key result
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No protein binding alerts were identified for the constituent 1,3-dimethyl-1,1,3,3-tetraphenyldisiloxane.
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- other: in silico tool
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Principles of method if other than guideline:
- Profilers:
General Mechanistic
Protein binding potency GSH
Protein binding by OECD
Protein binding by OASIS
Protein binding potency Cys (DPRA 13%)
Protein binding potency Lys (DPRA 13%)
Endpoint Specific
Protein binding alerts for skin sensitization according to GHS
Protein Binding Potency h-CLAT
Protein binding alerts for Chromosomal aberration by OASIS
Protein binding alerts for skin sensitization by OASIS - Type of study:
- other: in silico tool
- Key result
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No protein binding alerts were identified for the constituent 1,3,3,5,5,7-hexamethyl-1,1,7,7-tetraphenyltetrasiloxane.
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- other: in silico tool
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Principles of method if other than guideline:
- Profilers:
General Mechanistic
Protein binding potency GSH
Protein binding by OECD
Protein binding by OASIS
Protein binding potency Cys (DPRA 13%)
Protein binding potency Lys (DPRA 13%)
Endpoint Specific
Protein binding alerts for skin sensitization according to GHS
Protein Binding Potency h-CLAT
Protein binding alerts for Chromosomal aberration by OASIS
Protein binding alerts for skin sensitization by OASIS - Type of study:
- other: in silico tool
- Key result
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No protein binding alerts were identified for the constituent 1,3,3,5-tetramethyl-1,1,5,5-tetraphenyltrisiloxane
- Endpoint:
- skin sensitisation: in vitro
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- other: in silico tool
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Principles of method if other than guideline:
- Toxtree Module: Skin sensitisation reactivity domains
Identification of mechanisms of toxic action for skin sensitisation using a SMARTS pattern based approach.
Reference: Enoch SJ, Madden JC, Cronin MT,Identification of mechanisms of toxic action for skin sensitisation using a SMARTS pattern based approach.,SAR QSAR Environ Res. 2008;19(5-6):555-78.
Includes alerts for:
QSNAR.SNAr-Nucleophilic Aromatic Substitution
QSB.Schiff Base Formation
QMA.Michael Acceptor
Qacyl.Acyl Transfer Agents
QSN2.SN2-Nucleophilic Aliphatic Substitution
Q6.At least one alert for skin sensitisation? - Type of study:
- other: in silico tool
- Key result
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No skin sensitisation reactivity domains alerts were identified for the constituent 1,3-dimethyl-1,1,3,3-tetraphenyldisiloxane
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- other: in silico tool
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Principles of method if other than guideline:
- Toxtree Module: Skin sensitisation reactivity domains
Identification of mechanisms of toxic action for skin sensitisation using a SMARTS pattern based approach.
Reference: Enoch SJ, Madden JC, Cronin MT,Identification of mechanisms of toxic action for skin sensitisation using a SMARTS pattern based approach.,SAR QSAR Environ Res. 2008;19(5-6):555-78.
Includes alerts for:
QSNAR.SNAr-Nucleophilic Aromatic Substitution
QSB.Schiff Base Formation
QMA.Michael Acceptor
Qacyl.Acyl Transfer Agents
QSN2.SN2-Nucleophilic Aliphatic Substitution
Q6.At least one alert for skin sensitisation? - Type of study:
- other: in silico tool
- Key result
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No skin sensitisation reactivity domains alerts were identified for the constituent 1,3,3,5,5,7-hexamethyl-1,1,7,7-tetraphenyltetrasiloxane
- Endpoint:
- skin sensitisation: in vitro
- Type of information:
- other: in silico tool
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Principles of method if other than guideline:
- Toxtree Module: Skin sensitisation reactivity domains
Identification of mechanisms of toxic action for skin sensitisation using a SMARTS pattern based approach.
Reference: Enoch SJ, Madden JC, Cronin MT,Identification of mechanisms of toxic action for skin sensitisation using a SMARTS pattern based approach.,SAR QSAR Environ Res. 2008;19(5-6):555-78.
Includes alerts for:
QSNAR.SNAr-Nucleophilic Aromatic Substitution
QSB.Schiff Base Formation
QMA.Michael Acceptor
Qacyl.Acyl Transfer Agents
QSN2.SN2-Nucleophilic Aliphatic Substitution
Q6.At least one alert for skin sensitisation? - Type of study:
- other: in silico tool
- Key result
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No skin sensitisation reactivity domains alerts were identified for the constituent 1,3,3,5-tetramethyl-1,1,5,5-tetraphenyltrisiloxane
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Justification for classification or non-classification
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