Registration Dossier
Registration Dossier
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EC number: 203-271-5 | CAS number: 105-11-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because skin contact in production and/or use is not likely
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
In accordance with REACH Regulation (EC) No. 1907/2006 Annex VII, column 2 section 8.5 (as amended by Commission Regulation (EU) 2016/863) the acute dermal toxicity (OECD TG 402) study does not need to be conducted based on available information. In addition to the oral route, the information required in sub-section 8.5.2 and 8.5.2 should be provided for at least one other route. The data via the oral route indicates that the acute oral toxicity LD50 < 2000 mg/kg bw. The data in an available inhalation (OECD TG 436) study indicates that the LC50 > 5.0 mg/L. Testing via the dermal route is not deemed required as sufficient information has been provided for the information requirement and exposure to humans via the dermal route is considered unlikely during use. According to ECHA Guidance on Information Requirements and Chemical Safety Assessment (Chapter R.7a: Endpoint Specific Guidance, R.7.4, July 2017) the study does not need to be conducted.
Data source
Materials and methods
Results and discussion
- Clinical signs:
- other:
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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