Registration Dossier
Registration Dossier
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EC number: 213-126-8 | CAS number: 925-83-7
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 Aug 2018 - 16 Oct 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
- Version / remarks:
- 1996
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Sebacohydrazide
- EC Number:
- 213-126-8
- EC Name:
- Sebacohydrazide
- Cas Number:
- 925-83-7
- Molecular formula:
- C10H22N4O2
- IUPAC Name:
- sebacohydrazide
- Test material form:
- solid: particulate/powder
- Details on test material:
- Test item name (as stated in report): SDH
Test item storage: at room temperature protected from light
Constituent 1
Study design
- Analytical method:
- other: UPLC-MS/MS
Results and discussion
Partition coefficientopen allclose all
- Key result
- Type:
- log Pow
- Partition coefficient:
- -0.8
- Temp.:
- 20 °C
- pH:
- >= 7.3 - <= 7.4
- Remarks on result:
- other: no buffer applied
- Key result
- Type:
- Pow
- Partition coefficient:
- 0.17
- Temp.:
- 20 °C
- pH:
- >= 7.3 - <= 7.4
- Remarks on result:
- other: no buffer applied
- Details on results:
- - Concentration analysed in the stock solution was 97.7 mg/L.
- Nominal quantity of the substance in each test sample: 0.195 mg.
- Recovery (range) for the test samples: 100% - 105%.
- The log Pow values were within the criterion range of ± 0.3 log units (see table below)
Any other information on results incl. tables
Table: Shake-flask results
Ratio |
Analyzed concentration |
Pow |
log Pow |
pH |
||
n-octanol |
water |
individual |
mean |
|||
1:1 |
0.00481 |
0.0281 |
1.7x10-1 |
1.7x10-1 |
-0.8 |
7.4 |
|
0.00452 |
0.0282 |
1.6x10-1 |
|
-0.8 |
7.4 |
1:2 |
0.00393 |
0.0228 |
1.7x10-1 |
1.7x10-1 |
-0.8 |
7.4 |
|
0.00394 |
0.0236 |
1.7x10-1 |
|
-0.8 |
7.4 |
2:1 |
0.00649 |
0.0361 |
1.8x10-1 |
1.8x10-1 |
-0.7 |
7.3 |
|
0.00632 |
0.0368 |
1.7x10-1 |
|
-0.8 |
7.3 |
Mean |
1.7x10-1 |
|
-0.8 |
|
||
Standard deviation |
6.5x10-3 |
|
|
|
||
Applicant's summary and conclusion
- Conclusions:
- The log Pow of the substance at neutral pH and 20°C was determined to be -0.8.
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