Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-129-1 | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (28d) = 1.8 mg/L (active ingredient, mortality) for Danio rerio (OECD 204, read across)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.8 mg/L
Additional information
No study investigating the long-term toxicity of D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, carboxymethyl ethers, sodium salts (CAS 383178-66-3) to freshwater fish is available.Thus, an analogue substance (D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, CAS 110615-47-9) is used in a read across approach to assess the algal toxicity of the target substance to freshwater algae. The read across is based on structural similarity between the target substance and the supporting substance. The target substance is a derivative of the supporting substance, where a carboxymethy group is added to a -OH function. All other structural elements (alkyl side chain, glycoside moiety) are identical. The additional carboxymethyl group renders the substance more hydrophilic, which usually decreases aquatic toxicity. This is confirmed by the acute ecotox data of the target substance (TS) and the supporting substance (SS): Fish: 7.1 mg/L (TS) vs 3.0 mg/L (SS); Invertebrates: 172 mg/L (TS) vs 7.0 mg/L (SS). Therefore, read across from D-Glucopyranose, oligomeric, C10-16-alkyl glycosides to D-Glucopyranose, oligomeric, C10-16-alkyl glycosides, carboxymethyl ethers, sodium salt is fully justified as this is considered to be a worst case approach.
The toxicity of the read across substance to the zebrafish Brachydanio rerio was tested in a prolonged fish toxicity test according to OECD guideline 204 ("Fish, prolonged toxicity test: 14-day study") for 28 days (Hooftman 1995). This test can be used as a long-term test because the following criteria are fulfilled: the duration is 28 days, the tested fish life stage is equal to OECD 215 and additional parameters like behaviour and growth were investigated (according to “Guidance Document on Aquatic Ecotoxicology” published by the European Commission (2002)). The test exhibited a NOEC of 1.8 mg a.i./L after 28 days for the endpoint mortality and a NOEC of 3.2 mg a.i./L for the endpoint growth, respectively. No behavioral abnormalities were observed in the non-toxic concentrations of the test substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
