Registration Dossier
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EC number: 814-171-1 | CAS number: 123739-10-6
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 October 2017 - 23 March 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
- Version / remarks:
- 1996
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- DEPDA adduct
- Cas Number:
- 123739-10-6
- IUPAC Name:
- DEPDA adduct
- Test material form:
- solid
- Details on test material:
- - Physical appearance: dark amber solid
- Storage conditions: at room temperature
Constituent 1
Study design
- Analytical method:
- other: Visual observation
Results and discussion
Partition coefficientopen allclose all
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 5
- Temp.:
- 20 °C
- Remarks on result:
- other: neutral pH
- Type:
- Pow
- Partition coefficient:
- > 100 000
- Temp.:
- 20 °C
- Remarks on result:
- other: neutral pH
- Details on results:
- Experiment 1:
all test item had dissolved (n-ocatnol solubility is > 230 mg/L)
Experiment 2:
all test item had dissolved (n-octanol solubility is > 100 g/L)
Experiment 3:
Test item had not completely dissolved
Experiment 4:
all test item had dissolved (n-octanol solubility is > 1000 g/L)
Based on experiment 4 it was concluded that the n-octanol solubility of INCA 460: DEPDA adduct. is > 1000 g/L.
The water solubility was found to be < 10 mg/L. Using this value and a n-octanol solubility of > 1000 g/L, the Pow of the test item at 20°C was estimated to be > 100000. It corresponds with a log Pow value of > 5.
Applicant's summary and conclusion
- Conclusions:
- The Pow of the substance at 20°C was estimated to be 100000 (log Pow > 5).
- Executive summary:
The log Pow of the INCA 460: DEPDA adduct was estimated from the ratio n-octanol solubility and water solubility in a GLP study according to EC A.8, OECD 107 and OPPTS 830.7550.
The Powvalue of the test item at 20°C was > 100000 which corresponds with a log Powvalue of > 5.
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