Triphenyl phosphite

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1980

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

Study performed according to Section 1500.3 Federal Hazardous Substances Act Regulations - 16 CFR - P. 114.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Triphenyl phosphite

EC Number:

202-908-4

EC Name:

Triphenyl phosphite

Cas Number:

101-02-0

Molecular formula:

C18H15O3P

IUPAC Name:

triphenyl phosphite

Details on test material:

- Name of test material (as cited in study report): Triphenyl Phosphite
- Lot/batch No.: TPPX-Z18-04080A (Borg Warner)

Test animals

Species:

rat

Strain:

other: Sherman-Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 200 and 300 g
- Fasting period before study: yes, overnight
- Housing: in compliance with the Animal Welfare Act (Pub. L-94-279) 9 CFR Part 3.
- Diet: ad libitum
- Water: ad libitum

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

males: 1000, 1260, 1410, 1580, 2000, 2510, 3160, 3980 mg/kg bw
females: 1000, 1260, 1580, 1780, 2000, 2510, 3160, 3980 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 21 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Statistics:

The LD50 was calculated employing the method described in the following publication: Finney, D. J. Statistical Methods in Biological Assay, Second Edition, London Griffin Press 1971.

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LD50

Effect level:

1 590 mg/kg bw

Based on:

test mat.

Effect levels 2

Sex:

female

Dose descriptor:

LD50

Effect level:

1 630 mg/kg bw

Based on:

test mat.

Mortality:

All male animals of dose groups 2000 mg/kg and higher died on the first day. At 1580 mg/kg, 2 males died, and at 1410 mg/kg, one male died.
All female animals of dose groups 2000 mg/kg and higher died on the first day. At 1780 mg/kg, 3 females died. At 1580 and at 1260 mg/kg one female died.

Clinical signs:

other: Males: At lower dose levels animals were slightly depressed and ruffled. At 1580 mg/kg the animals were moderately depressed, ruffled and drooling. Several aninals became severely depressed and/or seni-comatose after 3-4 hours. These effects were reversi

Gross pathology:

Gross pathologic examination revealed nothing remarkable.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

Based on the results of this acute oral toxicity study in Sherman-Wistar rats, the LD50 was set to 1590 mg/kg bw for males and 1630 mg/kg bw for females.