3-(triethoxysilyl)propyl methacrylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

05 October 1995-08 May 1995

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1995

Report date:

1995

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: U.S. EPA FIFRA/TSCA and Japanese MAFF guidelines

GLP compliance:

yes

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

3-(triethoxysilyl)propyl methacrylate

EC Number:

244-239-0

EC Name:

3-(triethoxysilyl)propyl methacrylate

Cas Number:

21142-29-0

Molecular formula:

C13H26O5Si

IUPAC Name:

3-(triethoxysilyl)propyl 2-methylprop-2-enoate

Test material form:

liquid

Remarks:

clear, colourless

Test animals

Species:

rat

Strain:

other: Crl:CDBR

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Charles River, NY
- Age at study initiation: young adult
- Weight at study initiation: 217 - 278 g
- Fasting period before study:
- Housing: Individual housing, suspended wire mesh cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: minimum of 7 days

ENVIRONMENTAL CONDITIONS
- Temperature (°F): 71.3-72.1
- Humidity (%): 42.3-62.5
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED: 5.05 ml/kg

Doses:

5000 mg/kg bw

No. of animals per sex per dose:

5M/5F

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: the rats were observed 1, 3 and 4 hours post-dose on day 0 and twice daily thereafter. Body weights were obtained and recorded on study days -1, 0, 7, 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Major organ systems of the cranial, thoracic and abdominal cavities were examined for all animals.

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

There were no deaths during the study.

Clinical signs:

other: All clinical findings were within three days of dosing. Wet yellow urogenital staining was observed for nine animals. Mucoid faeces and soft stool were each noted for single animals. One rat had dried red material on the forelimbs. There were no other cli

Gross pathology:

Enlarged cervical lymph nodes were observed for a single animal at the terminal necropsy. There were no other necropsy findings.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

An LD50 of >5000 mg/kg bw is reported for the registered substance in a study that was conducted according to current guideline and in compliance with GLP.