Registration Dossier
Registration Dossier
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EC number: 947-971-5 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Relevant studies were reviewed by a qualified toxicologist with a view to fulfilling the requ irements of Annex VIII (8.8.1).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- In accordance with REACH Annex VIII (8.8.1) an assessment of toxicokinetic behaviour has been conducted to the extent that can be derived from the relevant available information. The assessment is based on the Guidance on information requirements and chemical safety assessment R.7c: Endpoint specific guidance (ECHA, May 2008)
- GLP compliance:
- no
Test material
- Specific details on test material used for the study:
- REACTION MASS OF BIS(2-ETHYLHEXYL) HYDROGEN PHOSPHATE AND 2-ETHYLHEXYL D
IHYDROGEN PHOSPHATE
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The available information suggests that absorption of the test substance from the gastrointestinal tract
can take place. Some absorption may also take place via the skin. Once absorbed, the substance
would be distributed in the serum and urine is the significant route of excretion. There is no evidence
to suggest that the test substance may be metabolised, however no studies have been conducted to
identify metabolites. - Executive summary:
The available information suggests that the substance is readily available via the oral route; however, absorption via the skin is also possible. This is supported by the physicochemical properties of the
substance. Once absorbed, the substance would result in distribution in the serum. There is no evidence to indicate the route of excretion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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