Hexyl benzoate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1951

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Reliability has been presented as 2 because similar to OECD Guideline protocol has been followed but not GLP.

Data source

Reference

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List IV

Author:

Smyth, H.F., Carpenter, C.P., Weil, C.S.

Year:

1951

Bibliographic source:

A.M.A. archives of industrial hygiene and occupational medicine (1951), American Medical Association, 4 (2) p.119-22

Report date:

1951

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

fixed dose procedure

Limit test:

yes

Test material

Test material information

1

Reference substance name:

Hexyl benzoate

EC Number:

229-856-5

EC Name:

Hexyl benzoate

Cas Number:

6789-88-4

Molecular formula:

C13H18O2

IUPAC Name:

hexyl benzoate

Test material form:

liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: not indicated
- Age at study initiation: not indicated
- Weight at study initiation: 90-120 g
- Fasting period before study: no
- No details on housing, diet or environmental conditions were provided.

IN-LIFE DATES: not indicated

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

Six male rats were given a single dose. The size of the initial dosage was judged by previous experience with hundreds of other materials. Doses started at 10 g/kg bw and decreased with a factor 10. The test solution was always diluted with water or dispersed in water so that reasonable accuracy in volume measurement was possible. One week later, six more animals were given some other dosage and this procedure was repeated until two dosages differing by a multiple of ten were found, one of which within fourteen days killed some or all animals and the other of which killed some or no animals.

Doses:

Not spcecified

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

No further details were provided.

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

12 300 mg/kg bw

Based on:

test mat.

95% CL:

> 11 300 - < 13 500

Mortality:

No information on mortality was provided.

Clinical signs:

other: No information on observed clinical signs was provided.

Applicant's summary and conclusion

Interpretation of results:

other: Not acute harmful

Remarks:

according to Regulation (EC) No. 1272/2008 and its amendments.

Conclusions:

The acute oral toxicity test with the substance showed an LD50 of 12300 mg/kg bodyweight.

Executive summary:

In the oral toxicity study the substance was assessed for acute toxicity. 6 male rats were exposed to the substance by gavage using a fixed dose procedure. This procedure was repeated after 14 days, until two doses were found that provided sufficient information for determining an LD50. The LD50 for the substance was 12300 mg/kg bodyweight.