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Diss Factsheets
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EC number: 216-322-1 | CAS number: 1559-34-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Before OECD Guideline 404 was established in 1982, skin irritation was tested using an internal method (BASF test). White Vienna rabbits were used. 2 animals were treated for 20 hours using occlusive conditions. An application site of 2.5x2.5 cm was covered with the liquid test substance. In addition, skin tissue from the ear was tested by wrapping the ear. These results from the ear, however, would not be taken into account for evaluation as they do not represent testing of the dorsal / lateral flank of the back.
After the application time, the skin was washed with water which sometimes contained a mild detergent.
The animals were observed for 8 days and skin changes were recorded on working days.
The report usually describes findings after 24 hours and at the end of the observation period. Thus, for final evaluation, the findings after 48 and 72 hours from the raw data have to be taken into account.
The original BASF grading was converted into the numerical grading according to the OECD Draize system. - GLP compliance:
- no
Test material
- Reference substance name:
- 3,6,9,12-tetraoxahexadecan-1-ol
- EC Number:
- 216-322-1
- EC Name:
- 3,6,9,12-tetraoxahexadecan-1-ol
- Cas Number:
- 1559-34-8
- Molecular formula:
- C12H26O5
- IUPAC Name:
- 3,6,9,12-tetraoxahexadecan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Butyltetraglykol, Tetraäthoxybutanol
- Molecular formula (if other than submission substance): C4H9(OC2H4)4-OH
- Physical state: liquid
- Analytical purity: 90%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): approx. 1 ml - Duration of treatment / exposure:
- 20 hours
- Observation period:
- 8 days
- Number of animals:
- 2 animals (one male and one female)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- no clinical signs visible after 24 hours or 8 days on dorsal skin;
(slight redness visible after 24 hours on the skin of the ear, which was totally recovered after 8 days)
Any other information on results incl. tables
The original BASF grading was converted into the numerical grading according to the OECD Draize system.
Incubation time |
24 hours after application |
8 days after application |
||
Animal 1 |
Animal 2 |
Animal 1 |
Animal 2 |
|
1 min |
||||
5 min |
||||
15 min |
||||
20 hours |
0 |
0 |
0 |
0 |
Draize Dermal Irritation Scoring System:
Erythema and Eschar Formation |
Value |
Edema Formation |
Value |
No erythema Very slight erythema (barely perceptible) Well defined erythema Moderate to severe erythema Severe erythema (beet-redness) to slight, eschar formation (injuries in depth) |
0 1 2 3 4 |
No edema Very slight edema (barely perceptible) Slight edema (edges of area well defined by definite raising) Moderate edema (raised approx. 1 mm) Severe edema (raised more than 1 mm and extending beyond the area of exposure) |
0 1 2 3 4 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
An old but well reported skin irritation study is available. This study followed the basic principles of the current OECD guideline. White Vienna rabbits were used. 2 animals were treated for 20 hours of dermal exposure to the substance 3,6,9,12-tetraoxahexadecan-1-ol under occlusive conditions. No adverse skin reaction was seen. On this basis, the substance does not warrant classification as a skin irritant.
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