Carnosine

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

21 Dec 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.1 (Test method for readily combustible solids)

GLP compliance:

no

Key result

Test procedure:

burning rate test: preliminary screening test

Remarks on result:

substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period

Preliminary Study (Screening Test)

The test item was not flammable within 2 minutes by the flame of a gas burner within the ignition zone (the first 50 mm of the formed test item).

When the white powdery test item was directly exposed to the hot burner flame, it melted into drops, which merged together, carbonized and became bigger. This dark grey solid residue glowed orange in the burner flame, while yellow-orange flames and grey smoke could be observed, which extinguished immediately after removing the burner flame.

 

Definitive Study (Burning Rate Test)

The performance of the definitive study was not necessary.

 

Conclusions

The test item has to be classified as ‘Not readily combustible solid of Division 4.1’ in the sense of the test guideline UN Test N.1.

Interpretation of results:

not classified based on GHS criteria

Conclusions:

The substance is not flammable according to UN Test N.1 and has not to be classified as flammable solid according to GHS / CLP Regulation EC 1272/2008 Annex 1: 2.7.

Reference 2

Endpoint:

self-heating substances / mixtures

Type of information:

experimental study

Adequacy of study:

key study

Study period:

11 Apr 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

other: Recommendations on the TRANSPORT OF DANGEROUS GOODS: Manual of Tests and Criteria: Appendix 6 Screening Procedures, Division 4.2: Substances which may be liable to spontaneous combustion

Version / remarks:

6th edition, New York and Geneva, 2015

Qualifier:

according to guideline

Guideline:

other: VDI 2263, sheet 1, Grewer Oven

Version / remarks:

1990

GLP compliance:

no

Key result

Max. temp. reached:

420

Result:

other: slight self-heating observed

Results

The results of the Grewer Oven experiment are summarized in the next table.

Experiment	Onset self-ignition / °C	Maximum temperature / °C
Pure test item	---	420
Test item in mixture with Kieselguhr (1:1)	250	450

 

In the investigation of self-ignition in the Grewer Oven for the pure test item a small exothermic effect started at 220 °C and increased to 245 °C, directly followed by an endothermic process. After this the temperature of the test item was permanent over the reference temperature (6 - 8 K) until the maximum temperature of 420 °C (415 °C reference temperature). This effect is explained to changing the condition of the pure test item. After the measurement the test item was fluffy.

For the test item in mixture with Kieselguhr a small exothermic effect was observed at 220 °C and the temperature increased to 245 °C. After this the temperature is fallen down to the reference temperature. Above 250 °C a permanent temperature rise was observed until the maximum temperature of 450 °C (415 °C reference temperature).

 

 

Final Results / Classification

The pure test item indicated a slight self-heating but no self-ignition at atmospheric pressure until the maximum test temperature of 420 °C.

UN Transport Regulation: The test item has not to be classified as self-heating substance in class 4, division 4.2 according to the UN Transport Regulation.

GHS / CLP Regulation EC 1272/2008 Annex 1: 2.11: The test item has not to be classified as self-heating substance according to GHS/CLP Regulation EC 1272/2008 Annex 1: 2.11.

Interpretation of results:

not classified based on GHS criteria

Conclusions:

The pure test item indicated a slight self-heating but no self-ignition at atmospheric pressure until the maximum test temperature of 420 °C. The test item has not to be classified as self-heating substance in class 4, division 4.2 according to the UN Transport Regulation.

Description of key information

non flammable

no pyrophoricity

no flammability on contact with water

not self-heating

Key value for chemical safety assessment

Flammability:

not classified

Additional information

The test item has to be classified as ‘Not readily combustible solid of Division 4.1’ in the sense of the test guideline UN Test N.1.

Based on the chemical structure and experience in handling and use, pyrophoricity and flammability on contact with water are not expected.

The test item has not to be classified as self-heating substance in class 4, division 4.2 according to the UN Transport Regulation.

Justification for classification or non-classification

The substance has not to be classified as ‘flammable solid’ according to GHS / CLP Regulation EC 1272/2008 Annex 1: 2.7.

The substance has not to be classified as 'self-heating substance' according to GHS/CLP Regulation EC 1272/2008 Annex 1: 2.11.

The available data on flammability in contact with water and pyrophoricity of the test substance do not meet the criteria for classification according to Regulation (EC) 1272/2008, and are therefore conclusive but not sufficient for classification.

Based on the chemical structure and experience in handling and use, pyrophoricity and flammability on contact with water are not expected.