Myo-inositol

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: Collaborative International Pesticides Analytical Council Handbook, MT 59, Sieve Analysis

Deviations:

no

GLP compliance:

yes

Type of method:

sieving

Type of particle tested:

primary particle

Type of distribution:

mass based distribution

Key result

Remarks on result:

other: Approximately 96% of the test substance had particles residing in the range from 355 to 45 microns

No.:

#1

Size:

>= 250 µm

Distribution:

ca. 38 %

No.:

#2

Size:

<= 250 µm

Distribution:

ca. 60 %

No.:

#3

Size:

<= 20 µm

Distribution:

ca. 0 %

Remarks on result:

other: distribution was negligible at <20 μm

No sieve clogging or static issues were observed at any point during the testing. The mean weight percent recovery for the two analyses was 97.5%. The particle size distribution dramatically dropped off below 45 microns.

 

Particle Size Distribution Recovery Rate for Run 1
Sieve Size (µm)	Beaker Weight (empty; g)	Beaker Weight (w/residue; g)	Residue Weight (g)	Percent Recovered1
1000	104.8607	104.8620	0.0013	0.0
710	113.1891	113.2000	0.0109	0.4
500	109.6950	109.7301	0.0351	1.1
355	116.4672	116.7791	0.3119	10.1
250	111.2868	112.0832	0.7964	25.9
180	118.8086	119.3620	0.5534	18.0
125	116.3299	116.8759	0.5460	17.7
90	104.7321	105.1069	0.3748	12.2
63	116.3155	116.5788	0.2633	8.6
45	108.9586	109.0340	0.0754	2.4
32	110.0988	110.1024	0.0036	0.1
20	113.1525	113.1526	0.0001	0.0
<20	46.5665	46.5667	0.0002	0.0
Initial sample weight (g): 3.0795 Total weight recovered from sieves (g) = 2.9724 Total percent recovered: 96.5% 1 Generated using Microsoft® Excel in full precision mode. Manual calculations may vary slightly.

 

Particle Size Distribution Recovery Rate for Run 2
Sieve Size (µm)	Beaker Weight (empty; g)	Beaker Weight (w/residue; g)	Residue Weight (g)	Percent Recovered1
1000	112.9001	112.9015	0.0014	0.0
710	111.2229	111.2324	0.0095	0.3
500	109.9475	109.9826	0.0351	1.2
355	109.7424	110.0445	0.3021	10.0
250	115.9331	116.7386	0.8055	26.6
180	110.6252	111.1446	0.5194	17.1
125	115.5298	116.0934	0.5636	18.6
90	112.9665	113.3393	0.3728	12.3
63	114.0950	114.3648	0.2698	8.9
45	110.0893	110.1926	0.1033	3.4
32	108.6427	108.6472	0.0045	0.1
20	116.1001	116.1003	0.0002	0.0
<20	46.5665	46.5666	0.0001	0.0
Initial sample weight (g): 3.0338 Total weight recovered from sieves (g) = 2.9873 Total percent recovered: 98.5% 1 Generated using Microsoft® Excel in full precision mode. Manual calculations may vary slightly.

 

Particle Size Distribution Recovery Rate: Range Determination
Sieve Size (µm)	% Recovery Data (Run 1)	% Recovery Data (Run 2)	Range (%)1
1000	0.0	0.0	0.0
710	0.4	0.3	0.1
500	1.1	1.2	0.1
355	10.1	10.0	0.1
250	25.9	26.6	0.7
180	18.0	17.1	0.9
125	17.7	18.6	0.9
90	12.2	12.3	0.1
63	8.6	8.9	0.3
45	2.4	3.4	1.0
32	0.1	0.1	0.0
20	0.0	0.0	0.0
<20	0.0	0.0	0.0
Range = Abs ((% recovery data Sieve 1) – (% recovery data Sieve 2)); calculated for each sieve size 1 Generated using Microsoft® Excel in full precision mode. Manual calculations may vary slightly.

 

Summary of Particle Size Distribution Recovery Rate: Mean Percent Recovery for Each Sieve
Sieve Size (µm)	Mean Percent Recovered
1000	0.0
710	0.3
500	1.1
355	10.0
250	26.2
180	17.5
125	18.2
90	12.2
63	8.7
45	2.9
32	0.1
20	0.0
<20	0.0
Total Mean Percent Recovery = 97.5 1 Generated using Microsoft® Excel in full precision mode. Manual calculations may vary slightly.

Conclusions:

ca. 38% of particulate matter was ≥250 μm
ca. 60% of particulate matter was <250 μm
Negligible (ca. 0%) amount of particulate matter was <20.0 μm

Executive summary:

The particle size distribution of the test substance was determined using dry sieve analysis for powder material according to OECD Guideline 110. Sieve analysis consisted of the quantitative separation of a powder or granular material into fractions with different ranges of particle size by use of an appropriate sieve or sieves. The dry sieve was performed by a process of shaking, tapping, brushing and weighing. The test was performed using a total of twelve test sieves with nominal aperture sizes ranging from 20.0 to 1000 μm (micron). The testing was performed in duplicate using two separate sub-samples. The test material subsample masses used were 3.0795 and 3.0338 grams. No sieve clogging or static issues were observed at any point during the testing. Approximately 96% of the test substance had particles residing in the range from 355 to 45 microns. The particle size distribution dramatically dropped off below 45 microns. The average amount of particulate matter either at or larger than 250 microns in the test substance was approximately 38%. The average amount of particulate matter smaller than 250 microns in the test substance was approximately 60%. The average amount of particulate matter smaller than 20.0 microns in the test substance was negligible. The mean weight percent recovery for the two analyses was 97.5%.

Description of key information

OECD Guideline 110

Additional information

Approximately 96% of the test substance had particles residing in the range from 355 to 45 microns