Registration Dossier
Registration Dossier
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EC number: 208-964-6 | CAS number: 549-18-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- publication
- Title:
- ChemIDplus - Amitriptyline hydrochloride
- Author:
- National Library of Medicine (US).
- Year:
- 2 018
- Bibliographic source:
- ChemIDplus [Internet]. Bethesda (MD): National Library of Medicine (US). Available from: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
Materials and methods
Test material
- Reference substance name:
- Amitriptyline hydrochloride
- EC Number:
- 208-964-6
- EC Name:
- Amitriptyline hydrochloride
- Cas Number:
- 549-18-8
- Molecular formula:
- C20H23N.ClH
- IUPAC Name:
- 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine hydrochloride
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 140 mg/kg bw
- Based on:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- For amitriptyline hydrochloride the mouse, LD50 by oral oral route was 140 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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