Phosphoric acid, mono- and di-C12-18-(even numbered)-alkyl esters, sodium salts

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size

Cross-reference

Reason / purpose for cross-reference:

data waiving: supporting information

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From February 26, 2015 to March 06, 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

not specified

Type of method:

dynamic method

Specific details on test material used for the study:

Batch no.: SEALS 211-104-06-01
Appearance: white, waxy solid

Key result

Temp.:

20 °C

Vapour pressure:

<= 9.6 Pa

Key result

Temp.:

50 °C

Vapour pressure:

<= 150 Pa

- The experimentally determined vapour pressure of the test substance at 20°C was not in the recommended range of 1 to 1000 mbar for DSC-measurements. Therefore, an estimation procedure in accordance with the test method OECD Guideline 104 was used. This method is applied for vapour pressures between 10³ and 10^-7mbar.

- The vapour pressure P for solids can be calculated using the an adapted equation for liquids.

 

Conclusions:

Under the study conditions, the vapour pressure of the test substance was determined to be ≤9.6 Pa at 20°C and ≤150 Pa at 50°C.

Executive summary:

A study was conducted to determine the vapour pressure of the test substance according to OECD Guideline 104 (Grain-Watson estimation) similar to the EU method A.4 (dynamic method). The practical test performance was based on the in-house test procedure VTA(S) 31X07001.01: ‘determination of the vapour pressure curve of solid and liquid substances by means of DSC’. Under the study conditions, the vapour pressure of the test substance was determined to be ≤9.6 Pa at 20°C and ≤150 Pa at 50°C (Kintrup, 2015).