Phenylphosphonic dichloride

Genetic toxicity: in vitro

Administrative data

Endpoint:

in vitro gene mutation study in bacteria

Data waiving:

other justification

Justification for data waiving:

other:

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
According to REACH Annex XI (2) testing may be omitted if it is technically not possible to perform the test. Phenylphosphonic dichloride reacts violently with water and is hydrolytically very unstable.
In water, phenylphosphonic dichloride hydrolyses to free phenylphosphonic acid and hydrochloric acid with t1/2 < 60 seconds.
The reaction of phenylphosphonic dichloride and water was studied by bringing a small amount of neat phenylphosphonic dichloide (i.e. 1 mL) into contact with an excess of well stirred water (i.e. 900 mL) and following the generation of acidic reaction products using a pH electrode. After 60 seconds the pH remained constant at 1.6 (see endpoint study record hydrolysis).
In addition the conductivity as a function of time was measured after adding phenylphosphonic dichloride to water.
The half-life of phenylphosphonic dichloride in water at 23 °C was therefore estimated to be < 60 seconds.
Since phenylphosphonic dichloride is a corrosive substance (pH in aqueous systems is 1.6) strong cytotoxicity is to be expected causing irreversible destruction of any marker cell system even at low concentrations. Therefore, to avoid marker cell destruction due to corrosivity, the concentration to be tested would have to be extremely low. As a consequence any results from these extremely low concentrations would not adequately represent realistic human exposure situations and therefore would not be indicative to assess any potential genotoxicity under realistic conditions.