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EC number: 284-628-2 | CAS number: 84961-40-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In an acute oral toxicity study conducted according to the OECD Guideline 401 in rats (BASF SE, 1981), the oral LD50 was determined to be ca. 1400 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- prior to GLP implementation
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: food depreviation 15 - 20 hours before test substance administration.
- Diet: standardized animal laboratory diet
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- Form of administration: suspension
Concentrations used: 16.5, 24.2, 35.6 % (w/v)
Administration volume: 5, 7.3, 10.8 mL/kg - Doses:
- 825, 1210, 1780, 2610, 3830 mg/kg bw
- No. of animals per sex per dose:
- 5
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 400 mg/kg bw
- Mortality:
- Males: 825 mg/kg: no deaths; 1210 mg/kg: 3/5 after 14 days; 1780 mg/kg: 1/5 after 14 days; 2610 mg/kg: 4/5 after 14 days; 3830 mg/kg: 5/5 after 14 days
Females: 825 mg/kg: no deaths; 1210 mg/kg: 3/5 after 14 days; 1780 mg/kg: 4/5 after 14 days; 2610 and 3830 mg/kg: 5/5 after 14 days - Clinical signs:
- other: Dyspnea, apathy, staggering, feces and urine orange-coloured, diarrhea, poor general state
- Gross pathology:
- Died animals:
heart: acute dilatation of the atrium; acute congestive hyperemia
organs/fat tissues/musculature: substance-coloured
Sacrificed animals:
organs: nothing abnormal detected - Interpretation of results:
- Category 4 based on GHS criteria
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 400 mg/kg bw
- Quality of whole database:
- Klimisch code 2
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the available study (BASF SE, 1981) the acute toxic effects of the test substance were investigated after a single oral gavage to rats. The investigations were performed in accordance with OECD guideline 401. The test substance (purity > 95 %) was (suspended in olive oil) administered once orally via gavage to fasted Sprague-Dawley rats (male/female, 5 animals/dose) at doses of 825, 1210, 1780, 2610, and 3830 mg/kg bw. Body weight was determined before administration and 14 days after the administration (p.a.). Clinical observations were performed at least once per day during the 14 days observation period and all animals were sacrificed and necropsied at the end of the observation period. Body weight development of both sexes was within the normal range of the rat strain. The following clinical signs were observed: dyspnea, apathy, staggering, diarrhea, and poor general state. Mortality after the 14 days observation period occurred at all dose groups except in the 825 mg/kg bw group (1210 mg/kg bw: 3/5, 1780 mg/kg bw: 1/5, 2610 mg/kg bw 4/5, 3830 mg/kg bw: 5/5). Based on the mortality, an LD50 of 1400 mg/kg bw was determined.
Justification for classification or non-classification
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008.
An LD50 of 1400 mg/kg bw for acute oral toxicity was determined. As a result, the substance is considered to be classified for acute oral toxicity (Category 4, H302) under Regulation (EC) No 1272/2008, as amended for the tenth time in Regulation (EU) No 2017/776.
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