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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
not reported
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Remarks:
They study was performed in accordance with generally accepted scientific principles. The study was presented as a short abstract, but appears sufficient to consider reliable.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report date:
1966

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Male and female Sprague-Dawley rats were exposed to the undiluted test material via oral gavage in an acute toxicity range finding test. Animals were exposed to the test material at dose levels that increased in of 0.1 fractional log intervals; 1580, 2000, 2510, 3160 mg/kg bw. Animals were subsequently observed for signs of mortality and any toxicologically significant effects.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzenesulfonic acid, mono- and dialkylation products with C16-20 (even numbered, branched and linear) olefins, barium salts, barium carbonate, overbased, including distillates (petroleum), hydrotreated, solvent-refined, solvent-dewaxed, or catalytic dewaxed, light or heavy paraffinic C15-C50
Molecular formula:
Not possible, UVCB
IUPAC Name:
Benzenesulfonic acid, mono- and dialkylation products with C16-20 (even numbered, branched and linear) olefins, barium salts, barium carbonate, overbased, including distillates (petroleum), hydrotreated, solvent-refined, solvent-dewaxed, or catalytic dewaxed, light or heavy paraffinic C15-C50

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
1580, 2000, 2510, 3160 mg/kg bw
No. of animals per sex per dose:
Two - three rats per sex per dose
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 310 mg/kg bw
Based on:
test mat.
95% CL:
2 010 - 2 655
Clinical signs:
other: Toxic symptoms included; tremors and weakness followed by collapse and dyspnoea

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Under the conditions of the test an oral LD50 of 2310 mg/kg bw was determined.
Executive summary:

The acute oral toxicity of the test material was determined in a range finding test. The LD50 of the test material is 2310 mg/kg bw.