[No public or meaningful name is available]

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: No OECD guideline or GLP defined.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Principles of method if other than guideline:

Acute toxicity: intraperitoneal; neurotoxicity

GLP compliance:

not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Not applicable

Molecular formula:

C19 H17 O4 P1

IUPAC Name:

Not applicable

Test animals

Species:

hen

Strain:

other: Leghorn

Sex:

female

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

unchanged (no vehicle)

Doses:

2,5; 5 ml/kg bw.

No. of animals per sex per dose:

5/sex/dose

Control animals:

not specified

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

> 5 000

Any other information on results incl. tables

Dose (ml/lg	Neurotoxicological result
2,5	0/4
5	3/4*

* = 2 animals killed earlier because of strong paresis (week 5)

Applicant's summary and conclusion

Conclusions:

The LD 50 was >5000 ml/kg bw (i.p., hen).

Executive summary:

DPK was administered i.p. to hens. A clear neurotoxic effect was shown at a dose of 5 ml/kg bw.

The LD 50 was >5000 ml/kg bw.