Registration Dossier
Registration Dossier
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EC number: 431-020-1 | CAS number: 41340-36-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-(7-ethyl-1H-indol-3-yl)ethanol
- EC Number:
- 431-020-1
- EC Name:
- 2-(7-ethyl-1H-indol-3-yl)ethanol
- Cas Number:
- 41340-36-7
- Molecular formula:
- C12H15NO
- IUPAC Name:
- 2-(7-ethyl-1H-indol-3-yl)ethan-1-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
Administration / exposure
- Vehicle:
- polyethylene glycol
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Mortality:
- Male: 200 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 200 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 2 - Clinical signs:
- Signs of toxicity related to dose levels:
Mortality:
Two females treated with 2000 mg/kg were found dead on test
day 2. All other animals survived until scheduled necropsy.
Clinical signs:
In all animals, treated with 2000 mg/kg, ataxia and sedation
were observed on test day 1. In two animals, ruffled fur was
evident and persisted in one animal until test day 6. In one
female, irregular respiration and ventral position were
noted before it was found dead. No clinical signs were
observed in all animals, treated at a dose level of 200
mg/kg.
Body weights:
The body weight of the surviving animals was within the
range commonly recorded for animals of this strain and age. - Gross pathology:
- Effects on organs:
No macroscopic findings were observed at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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