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Diss Factsheets
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EC number: 232-030-7 | CAS number: 7783-84-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Sensitization:
Based on the available data for the structurally similar read across substances and applying the weight of
evidence approach, it can be concluded that the target chemical will also tend to behave in a similar manner that of the read across substances. Therefore the target chemical was estimated to be not irritating to skin and it can be further classified under the category “Not Classified” as per CLP regulation.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation, other
- Remarks:
- in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Weight of evidence approach based on closely related chemicals
- Justification for type of information:
- Weight of evidence approach based on closely related chemicals
- Reason / purpose for cross-reference:
- read-across: supporting information
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- other: Weight of evidence approach based on closely related chemicals
- Principles of method if other than guideline:
- Weight of evidence approach based on closely related chemicals
- GLP compliance:
- not specified
- Type of study:
- other: Weight of evidence approach based on closely related chemicals
- Specific details on test material used for the study:
- - Name of test material: Ferric hypophosphite
- IUPAC name: iron(3+) ion triphosphinate
- Molecular formula: FeO6P3
- Molecular weight: 250.8084 g/mole
- Smiles : [Fe+3].[O-]P=O.[O-]P=O.[O-]P=O
- Inchl: 1S/Fe.3H3O2P/c;3*1-3-2/h;3*3H2,(H,1,2)/q+3;;;/p-3
- Substance type: Inorganic
- Physical state: Solid powder (white to grey) - Species:
- other: guinea pigs and humans
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- no data available
- No. of animals per dose:
- Weight of evidence approach based on closely related chemicals
- Details on study design:
- This study is based on the Weight of evidence approach based on closely related chemicals
- Challenge controls:
- Weight of evidence approach based on closely related chemicals
- Positive control substance(s):
- not specified
- Vehicle:
- not specified
- Concentration:
- Weight of evidence approach based on closely related chemicals
- No. of animals per dose:
- Weight of evidence approach based on closely related chemicals
- Details on study design:
- This study is based on the Weight of evidence approach based on closely related chemicals
- Statistics:
- This study is based on the Weight of evidence approach based on closely related chemicals
- Reading:
- other: This study is based on the Weight of evidence approach based on closely related chemicals
- Group:
- test chemical
- Clinical observations:
- no dermal reactions observed
- Remarks on result:
- no indication of skin sensitisation
- Cellular proliferation data / Observations:
- This study is based on the Weight of evidence approach based on closely related chemicals
- Interpretation of results:
- other: not sensitizing
- Conclusions:
- On the basis of available studies for the closely related substances, the weight of evidence approach was applied to assess the dermal sensitization potential for target substance.
Ferric hypophosphite was estimated to be not sensitizing to skin. - Executive summary:
Based on the available studies for the closely related chemicals, weight of evidence approach was applied to assess the dermal sensitization potential of Ferric hypophosphite.
LLNA was performed to evaluate the contact sensitivity of the test chemical.
Groups of female BALB/c mice (n=3) were treated with 5% of the test chemical in DMSO or DMSO alone by applying 25 microliters to the dorsum of both ears for three consecutive days. Four days following the initial application, draining lymph nodes were excised. A single cell suspension of LNC was prepared. Incorporation of [3H]TdR was measured, and recorded as mean cpm ± standard deviation (SD) per node of three mice for each group.The incorporation of [3H]TdR was measured using a liquid scintillation counter and expressed as mean counts per min (cpm) + standard deviation per node of three animals for each test group. Increases in [3H]TdR incorporation relative to vehicle-treated controls were calculated for each test group and expressed as stimulation indices (SI).
The SI value of the test chemical was 1.15. Since the SI value was below 3, EC3 value couldnot be calculated. Hence, the test chemical was considered to be not sensitizing to skin.
This is supported by a case study reported for a 52-year-old female patient was seen in the surgical ward after an operation developed itching and eruption on her abdomen with 48 hours of operation. The eruption spread to the areas beyond the bandage on her abdomen; rather ill-defined patches of erythema, papules, vesicles and erosions were observed. It was diagnosed as contact eczema. The patient was patch tested with all the ointments which were in contact with skin. Later it was deduced that ethanol. So a series of patch tests were performed on series of alcohols, aldehydes, ketones as well impurities present in alcohol to determine the contact sensitization potential.
2% solution of the test chemical in water did not cause any dermal sensitization.
Hence, the test chemical can be considered to be not sensitizing to skin.
Based on the available data for the closely related substances and applying the weight of evidence approach, it can be concluded that the target chemical will also tend to behave in a similar manner that of the read across substances. Therefore the target chemical was estimated to be not sensitizing to skin and it can be further classified under the category “Not Classified” as per CLP regulation.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Based on the available studies for the closely related chemicals, weight of evidence approach was applied to assess the dermal sensitization potential of Ferric hypophosphite.
LLNA was performed to evaluate the contact sensitivity of the test chemical.
Groups of female BALB/c mice (n=3) were treated with 5% of the test chemical in DMSO or DMSO alone by applying 25 microliters to the dorsum of both ears for three consecutive days. Four days following the initial application, draining lymph nodes were excised. A single cell suspension of LNC was prepared. Incorporation of [3H]TdR was measured, and recorded as mean cpm ± standard deviation (SD) per node of three mice for each group.The incorporation of [3H]TdR was measured using a liquid scintillation counter and expressed as mean counts per min (cpm) + standard deviation per node of three animals for each test group. Increases in [3H]TdR incorporation relative to vehicle-treated controls were calculated for each test group and expressed as stimulation indices (SI).
The SI value of the test chemical was 1.15. Since the SI value was below 3, EC3 value couldnot be calculated. Hence, the test chemical was considered to be not sensitizing to skin.
This is supported by a case study reported for a 52-year-old female patient was seen in the surgical ward after an operation developed itching and eruption on her abdomen with 48 hours of operation. The eruption spread to the areas beyond the bandage on her abdomen; rather ill-defined patches of erythema, papules, vesicles and erosions were observed. It was diagnosed as contact eczema. The patient was patch tested with all the ointments which were in contact with skin. Later it was deduced that ethanol. So a series of patch tests were performed on series of alcohols, aldehydes, ketones as well impurities present in alcohol to determine the contact sensitization potential.
2% solution of the test chemical in water did not cause any dermal sensitization.
Hence, the test chemical can be considered to be not sensitizing to skin.
Based on the available data for the closely related substances and applying the weight of evidence approach, it can be concluded that the target chemical will also tend to behave in a similar manner that of the read across substances. Therefore the target chemical was estimated to be not sensitizing to skin and it can be further classified under the category “Not Classified” as per CLP regulation.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available data for the closely related substances and applying the weight of evidence approach, it can be concluded that the target chemical will also tend to behave in a similar manner that of the read across substances. Therefore the target chemical was estimated to be not sensitizing to skin and it can be further classified under the category “Not Classified” as per CLP regulation.
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