bis(2-methylpropyl) perylene-dicarboxylate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

significant methodological deficiencies

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Principles of method if other than guideline:

The conducted Inhalation Risk Test demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at the temperature chosen for vapor generation. Young adult laboratory rats, 6 per sex, were exposed sequentially to the vapors generated by bubbling 200 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 h. No analytical determination of the atmosphere concentrations was performed. The nominal concentration usually can be calculated as quotient of the amount of the test substance weight loss during exposure. Group-wise documentation of clinical signs was performed over a 7 day study period. Body weight of groups was determined before the start of the study and at the end of the observation period in surviving animals. However, the inhalation hazard test is insufficient for non-volatile substances.

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

3,10-bis(2-methylpropyl) perylene-3,10-dicarboxylate; 3,9-bis(2-methylpropyl) perylene-3,9-dicarboxylate

EC Number:

616-749-7

Cas Number:

79869-59-3

Molecular formula:

C30H28O4

IUPAC Name:

3,10-bis(2-methylpropyl) perylene-3,10-dicarboxylate; 3,9-bis(2-methylpropyl) perylene-3,9-dicarboxylate

Details on test material:

- Analytical purity: 100%
- Name of test material (as cited in study report): Fluorolgruengold Misch. Nr. 27-3887

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

8 h

Concentrations:

4.78 mg/l

No. of animals per sex per dose:

6

Control animals:

other: Yes: 3 animals/sex

Details on study design:

- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Frequency of weighing: before exposure, 24 h, 48 h, 72h, 4 days and before sacrifice day 8

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 4.78 mg/L air (nominal)

Exp. duration:

8 h

Remarks on result:

other: Inhation (dust)

Mortality:

Control: 0/6
Test group: 0/12

Clinical signs:

other: no substance related clinical sings were noticed