Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 273-224-1 | CAS number: 68953-70-8 The complex combination of alkanolamines from the distillation of reaction products of ammonia and oxirane. It consists predominantly of triethanolamine, diethanolamine and higher amines from the reaction of triethanolamine and oxirane.
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No chronic effects on aquatic invertebrates are expected for AMIX TE
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 16 mg/L
Additional information
Experimental long-term toxicity data for AMIX TE (CAS 68953 -70 -8) are not available. ECETOC (2003) developed the Acute to Chronic Ratio (ACR) based on toxicity data from various tests with different aquatic species (fish and aquatic invertebrates). Depending on the applied pooling criteria ACR values (90%-ile) have been calculated for different aspects. The relevant ACRs have a range from 11.5 (narcotic mode of action) to 94.5 (substance data for individual species). As the key value for AMIX TE is rather high (48-h EC50 > 222 mg/L, BASF SE, 2010), the NOEC is expected to be larger than 1 mg/L. Therefore, it can be concluded that chronic effects are not expected.
A study on the long-term toxicity to aquatic invertebrates is available for the structurally similar substance 2,2’,2’’-Nitrilotriethanol (CAS 102 -71 -6). To determine the chronic toxicity of 2,2',2"-nitrilotriethanol to aquatic invertebrates, a non-GLP reproduction toxicity study was performed using Daphnia magna as test species. The test followed a method of the German Federal Environmental Agency which is similar to the OECD TG 211. The test was designed as a semi-static procedure with closed vessels and exposure period of 21 days. Test concentrations were analytically verified and deviated less than 20% from nominal concentrations. Parental mortality, number of offspring per animal and first appearance of offspring were determined. The most sensitive endpoint was parental mortality. The 21 -d NOEC for parental mortality was determined to be 16 mg/L. The 21 -d NOEC for reproduction was 125 mg/L, the NOEC for appearance of first offspring was 250 mg/L (Kuehn et al./UBA 1989; Kuehn et al., 1988).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
