Registration Dossier
Registration Dossier
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EC number: 206-033-9 | CAS number: 294-62-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 09/1964
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Method: other: Farbenfabriken Bayer AG; details described in sections "Test animals" and "Administration/Exposure"
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Cyclododecane
- EC Number:
- 206-033-9
- EC Name:
- Cyclododecane
- Cas Number:
- 294-62-2
- Molecular formula:
- C12H24
- IUPAC Name:
- cyclododecane
- Details on test material:
- IUCLID4 Test substance: "pure" cyclododecane, no further information
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- no details
Administration / exposure
- Type of coverage:
- other: applied on shaved skin as solution
- Vehicle:
- other: acetone and vegetable oil 1:10
- Details on dermal exposure:
- ADMINISTRATION:
- Doses per time period: single dose (gavage)
- Volume administered or concentration: 2 ml/kg bw
- applied on shaved skin as solution
- skin was shaved one day before administration of the substance - Duration of exposure:
- -Duration: 4 hours
- Doses:
- 500 mg/kg bw
- No. of animals per sex per dose:
- 5 male animals per dose
- Control animals:
- no
- Details on study design:
- -after exposure (for 4 hours) the substance was removed from skin with water and soap
-animals were observed for 7 days after exposure - Statistics:
- no information
Results and discussion
- Preliminary study:
- no information
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 500 mg/kg bw
- Mortality:
- no mortalities were observed
- Clinical signs:
- no clinical signs were observed
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- Author concludes that substance will not be resorbed in a detectable amount from the intact ventral skin of the rat.
Any other information on results incl. tables
RS-Freetext:
MORTALITY: none
CLINICAL SIGNS: none
Applicant's summary and conclusion
- Conclusions:
Mortalities, clinical symptoms and significant dermal resorption of the test substance were not observed in this study. The LD 50 was determined to be greater than 500 mg/kg bw for acute dermal toxicity in male rats under conditions of this study.- Executive summary:
In this study acute dermal toxicity of the substance cyclododecane was examined in male rats. Mortalities, clinical symptoms and significant dermal resorption of the test substance were not observed in this study. The LD 50 was determined to be greater than 500 mg/kg bw for acute dermal toxicity in male rats under conditions of this study.
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