Registration Dossier
Registration Dossier
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EC number: 250-317-5 | CAS number: 30737-19-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 60 minutes
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Performed to GLP according to recognised methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Dichromium trioxalate
- EC Number:
- 250-317-5
- EC Name:
- Dichromium trioxalate
- Cas Number:
- 30737-19-0
- Molecular formula:
- Cr2 (C2O4)3
- IUPAC Name:
- Dichromium trioxalate
- Test material form:
- solid: particulate/powder
Constituent 1
In vitro test system
- Test system:
- human skin model
- Source species:
- human
- Cell type:
- non-transformed keratinocytes
- Vehicle:
- unchanged (no vehicle)
- Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- Amount/concentration applied:
- The test item was applied topically to the corresponding tissues ensuring uniform covering.
- Duration of treatment / exposure:
- Triplicate tissues were treated with the test item for a period og 60 minutes
- Duration of post-treatment incubation (if applicable):
- 42 hours after washing
- Number of replicates:
- Three treatment replicates
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- Mean
- Value:
- ca. 59
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Other effects / acceptance of results:
- Positive control % viability ca 3.8%
Limit for classification is 50% viability
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Not considered irritating to skin
- Executive summary:
The relative mean viability of the test item treated tissues was 59% after a 60 minute exposure period and 42-Hour post-exposure incubation period.
The limit for classification as Skin Irrit 2 is 50% viabiity
The substance is therefore classified as non-irritant, but is borderline.
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