Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-107-9 | CAS number: 87189-25-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 September 2009 - 12 October 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- (2002)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- zinc(2+) 3-hydroxypropane-1,2-bis(olate)
- EC Number:
- 700-107-9
- Cas Number:
- 87189-25-1
- Molecular formula:
- (C3H6O3Zn)n
- IUPAC Name:
- zinc(2+) 3-hydroxypropane-1,2-bis(olate)
- Details on test material:
- - Substance type: Organic
- Physical state: Powder
- Storage condition of test material: At room temperature in the dark
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain as stated in the report: New Zealand white Crl:KBL (NZW) SPF
- Source: Charles River Laboratories, Research Models and Services, Germany GmbH, 88353 Kisslegg
- Age at study initiation: ca. 9 months
- Weight at study initiation: 2300 - 2700 g
- Housing: individually in terulan cages
- Diet ad libitum: Ssniff K-H maintenance diet for rabbits
- Water ad libitum: tap water
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12 / 12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- water
- Controls:
- other: untreated skin area served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 g (minimally moistened with highly deionised water) - Duration of treatment / exposure:
- 4 h
- Observation period:
- 0, 1, 24, 48 and 72 h after removal of the patch.
- Number of animals:
- 3 animals
- Details on study design:
- 0.5 g of moistened test article was applied to intact skin on a patch of 2.5 cm x 2.5 cm and covered with semiocclusive dressing. After removal of the patch the application area was washed off with Lutrol and Lutrol/water (1:1). Since no effects were observed within 72 h the study was discontinued therafter.
The evaluation of skin reactions was performed according to the quoted guidelines.
EVALUATION
For evaluation, the calculation of the mean values of erythema and edema for readings at 24, 48 and 72 hours were quoted. Additionally, the reversibility of the observed findings was taken into account.
The evaluation is based on the criteria of the OECD Harmonized Integrated Classification System that was in place on the date of report signature (November 2009)
SCORING SYSTEM
Erythema and eschar formation
Grading
0 No erythema
1 Very slight erythema (barely perceptible)
2 Well defined erythema
3 Moderate to severe erythema
4 Severe erythema (beet redness) to eschar formation preventing grading of erythema
Edema formation
Grading
0 No edema
1 Very slight edema (barely perceptible)
2 Slight edema (edges of area well defined by definite raising)
3 Moderate edema (raised approx. 1 mm)
4 Severe edema (raised more than 1 mm and extending beyond area of exposure)
Descriptions of any dermal findings not covered by this scale were recorded.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24; 48; 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: since no erythema was observed, not applicable
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: since no edema was observed, not applicable
- Other effects:
- No cutaneous reactions were observed in all animals during the study. No clinical signs of intoxication were reported in the study.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
